Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
Francesca De Giorgi, Ænora Letourneur, Marianna Kashyrina, Federica Zinghirino, Sandra Dovero, Nathalie Dutheil, Leslie-Ann Largitte, Marie-Laure Arotçarena, Erwan Bezard, Marie-Hélène Canron, Wassilios Meissner, Francesco De Nuccio, Dario Domenico Lofrumento, Florent Laferrière, François Ichas
Preprint - Research Square. 2024-02-07
10.21203/rs.3.rs-3921168/v1

GRK2‐ Targeted Knockdown as Therapy for Multiple System Atrophy
Miguel Lopez‐Cuina, Paul Guérin, Nathalie Dutheil, Christelle Martin, Thierry Leste Lasserre, Pierre‐Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard
Movement Disorders. 2023-04-24
10.1002/mds.29422

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
Marie-Laure Arotcarena, Sandra Dovero, Nathalie Biendon, Nathalie Dutheil, Vincent Planche, Erwan Bezard, Benjamin Dehay
Front. Bioeng. Biotechnol.. 2021-11-15
10.3389/fbioe.2021.762209

Impaired brain insulin signalling in Parkinson’s disease
Fares Bassil, Anna Delamarre, Marie‐Helene Canron, Nathalie Dutheil, Anne Vital, Marie‐Laure Négrier‐Leibreich, Erwan Bezard, Pierre‐Olivier Fernagut, Wassilios G. Meissner
Neuropathol Appl Neurobiol. 2021-08-17
10.1111/nan.12760

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons
Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
Sci. Adv.. 2020-10-01
10.1126/sciadv.abc4364

Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons
Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
. 2020-02-12
10.1101/2020.02.11.943670

Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard, Benjamin Dehay
JCI Insight. 2019-08-22
10.1172/jci.insight.129719

In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson's disease.
L Chansel-Debordeaux, M Bourdenx, S Dovero, V Grouthier, N Dutheil, A Espana, L Groc, C Jimenez, E Bezard, B Dehay
Gene Ther. 2017-11-16
10.1038/gt.2017.84

Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.
Fares Bassil, Paul A. Guerin, Nathalie Dutheil, Qin Li, Matthias Klugmann, Wassilios G. Meissner, Erwan Bezard, Pierre-Olivier Fernagut
Mov Disord.. 2017-05-29
10.1002/mds.27041

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.
Mathieu Bourdenx, Sandra Dovero, Michel Engeln, Simone Bido, Matthieu F. Bastide, Nathalie Dutheil, Isabel Vollenweider, Laetitia Baud, Camille Piron, Virginie Grouthier, Thomas Boraud, Grégory Porras, Qin Li, Veerle Baekelandt, Dieter Scheller, Anne Michel, Pierre-Olivier Fernagut, François Georges, Grégoire Courtine, Erwan Bezard, Benjamin Dehay
acta neuropathol commun. 2015-07-25
10.1186/s40478-015-0222-2

Systemic gene delivery to the central nervous system using Adeno-associated virus.
Mathieu Bourdenx, Nathalie Dutheil, Erwan Bezard, Benjamin Dehay
Front. Mol. Neurosci.. 2014-06-02
10.3389/fnmol.2014.00050

Adeno-associated virus Rep represses the human integration site promoter by two pathways that are similar to those required for the regulation of the viral p5 promoter.
N. Dutheil, S. C. Smith, L. Agundez, Z. I. Vincent-Mistiaen, C. R. Escalante, R. M. Linden, E. Henckaerts
Journal of Virology. 2014-05-14
10.1128/jvi.00412-14

Transcriptional analysis of the adeno-associated virus integration site.
N. Dutheil, E. Henckaerts, E. Kohlbrenner, R. M. Linden
Journal of Virology. 2009-09-16
10.1128/jvi.01754-09

Site-specific integration of adeno-associated virus involves partial duplication of the target locus.
E. Henckaerts, N. Dutheil, N. Zeltner, S. Kattman, E. Kohlbrenner, P. Ward, N. Clement, P. Rebollo, M. Kennedy, G. M. Keller, R. M. Linden
Proceedings of the National Academy of Sciences. 2009-04-16
10.1073/pnas.0806821106

Characterization of the mouse adeno-associated virus AAVS1 ortholog.
N. Dutheil, M. Yoon-Robarts, P. Ward, E. Henckaerts, L. Skrabanek, K. I. Berns, F. Campagne, R. M. Linden
Journal of Virology. 2004-07-27
10.1128/jvi.78.16.8917-8921.2004

Adeno-associated virus site-specifically integrates into a muscle-specific DNA region.
N. Dutheil, F. Shi, T. Dupressoir, R. M. Linden
Proceedings of the National Academy of Sciences. 2000-04-11
10.1073/pnas.080079397