Additive effect of distant Lewy bodies and tau seeds injections on nigral degeneration in macaques
Morgane Darricau, Valentine Kulifaj, Marie-Laure Arotcarena, Qin Li, Taxiarchis Katsinelos, William A. McEwan, Maria Xilouri, Benjamin Dehay, Erwan Bezard, Vincent Planche
npj Parkinsons Dis.. 2025-04-13
10.1038/s41531-025-00938-9

Biological definitions of synucleinopathies should be anchored in clinical trajectories and encompass the complex biology of the disease
David Bendetowicz, Vincent Planche, Erwan Bezard, Benjamin Dehay, Wassilios G Meissner
Journal of Parkinson’s Disease. 2025-02-04
10.1177/1877718X241313443

Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space
J. Estaun-Panzano, S. Nandi, Q. Gresil, E. Doudnikoff, C. Mazzocco, ML. Arotcarena, MH. Canron, B. Dehay, L. Cognet, E. Bezard
npj Parkinsons Dis.. 2024-12-30
10.1038/s41531-024-00850-8

A population of Insula neurons encodes for social preference only after acute social isolation in mice
Christelle Glangetas, Adriane Guillaumin, Elodie Ladevèze, Anaelle Braine, Manon Gauthier, Léa Bonamy, Evelyne Doudnikoff, Thibault Dhellemmes, Marc Landry, Erwan Bézard, Stephanie Caille, Anne Taupignon, Jérôme Baufreton, François Georges
Nat Commun. 2024-08-21
10.1038/s41467-024-51389-4

Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates
Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay
npj Parkinsons Dis.. 2024-08-01
10.1038/s41531-024-00757-4

Modeling Parkinson's Disease in Primates
Erwan Bezard, Margaux Teil, Marie-Laure Arotcarena, Gregory Porras, Qin Li, Benjamin Dehay
Cold Spring Harb Perspect Med. 2024-06-10
10.1101/cshperspect.a041612

Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice
Tiago F. Outeiro, Lorraine V. Kalia, Erwan Bezard, Juan Ferrario, Chin‐Hsien Lin, Mohamed Salama, David G. Standaert, Lolade Taiwo, Ryosuke Takahashi, Miquel Vila, Brit Mollenhauer, Per Svenningsson,
Movement Disorders. 2024-04-04
10.1002/mds.29802

Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
Francesca De Giorgi, Ænora Letourneur, Marianna Kashyrina, Federica Zinghirino, Sandra Dovero, Nathalie Dutheil, Leslie-Ann Largitte, Marie-Laure Arotçarena, Erwan Bezard, Marie-Hélène Canron, Wassilios Meissner, Francesco De Nuccio, Dario Domenico Lofrumento, Florent Laferrière, François Ichas
Preprint - Research Square. 2024-02-07
10.21203/rs.3.rs-3921168/v1

Une neuroprothèse spinale contre les déficits locomoteurs de la maladie de Parkinson
Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
Med Sci (Paris). 2024-01-01
10.1051/medsci/2023185

Tau seeds from Alzheimer's disease brains trigger tau spread in macaques while oligomeric‐Aβ mediates pathology maturation
Morgane Darricau, Changsong Dou, Remi Kinet, Tao Zhu, Li Zhou, Xianglei Li, Aurélie Bedel, Stéphane Claverol, Caroline Tokarski, Taxiarchis Katsinelos, William A. McEwan, Ling Zhang, Ran Gao, Mathieu Bourdenx, Benjamin Dehay, Chuan Qin, Erwan Bezard, Vincent Planche
Alzheimer's & Dementia. 2023-12-26
10.1002/alz.13604

Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A. Obeso, Erwan Bezard, Benjamin Dehay
npj Parkinsons Dis.. 2023-09-19
10.1038/s41531-023-00579-w

Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model
Ibrahim Kaya, Anna Nilsson, Dominika Luptáková, Yachao He, Theodosia Vallianatou, Patrik Bjärterot, Per Svenningsson, Erwan Bezard, Per E. Andrén
npj Parkinsons Dis.. 2023-07-26
10.1038/s41531-023-00558-1

GRK2‐ Targeted Knockdown as Therapy for Multiple System Atrophy
Miguel Lopez‐Cuina, Paul Guérin, Nathalie Dutheil, Christelle Martin, Thierry Leste Lasserre, Pierre‐Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard
Movement Disorders. 2023-04-24
10.1002/mds.29422

Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates
Fayard Audrey, Fenyi Alexis, Lavisse Sonia, Dovero Sandra, Bousset Luc, Tracy Bellande, Lecourtois Sophie, Jouy Christophe, Guillermier Martine, Jan Caroline, Gipchtein Pauline, Dehay Benjamin, Bezard Erwan, Melki Ronald, Hantraye Philippe, Aron Badin Romina
Neurobiology of Disease. 2023-03-01
10.1016/j.nbd.2023.106086

Monitoring α-synuclein aggregation.
Juan Estaun-Panzano, Marie-Laure Arotcarena, Erwan Bezard
Neurobiology of Disease. 2023-01-01
10.1016/j.nbd.2022.105966

Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates
Morgane Darricau, Taxiarchis Katsinelos, Flavio Raschella, Tomislav Milekovic, Louis Crochemore, Qin Li, Grégoire Courtine, William A McEwan, Benjamin Dehay, Erwan Bezard, Vincent Planche
Brain. 2022-11-16
10.1093/brain/awac428

A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine Induces Potent Immune Responses and Therapeutic Efficacy in Mice
Sabine Schmidhuber, Sandra Scheiblhofer, Richard Weiss, Mihály Cserepes, József Tóvári, Gabriele Gadermaier, Erwan Bezard, Francesca De Giorgi, Francois Ichas, Dirk Strunk, Markus Mandler
Vaccines. 2022-08-30
10.3390/vaccines10091432

The Zinc Ionophore Clioquinol Reduces Parkinson’s Disease Patient-Derived Brain Extracts-Induced Neurodegeneration
Margaux Teil, Evelyne Doudnikoff, Marie-Laure Thiolat, Sylvain Bohic, Erwan Bezard, Benjamin Dehay
Mol Neurobiol. 2022-08-02
10.1007/s12035-022-02974-5

Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andrén
npj Parkinsons Dis.. 2022-04-13
10.1038/s41531-022-00299-7

Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function.
Arotcarena ML, Soria FN, Cunha A, Doudnikoff E, Prévot G, Daniel J, Blanchard-Desce M, Barthélémy P, Bezard E, Crauste-Manciet S, Dehay B.
Aging cell.
10.1111/acel.13584

Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Ines Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Michele Morari, Wassilios G Meissner, María Trinidad Herrero, Miquel Vila, Jose A Obeso, Erwan Bezard, Benjamin Dehay
Brain. 2022-03-14
10.1093/brain/awab374

Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, François Ichas
Biomolecules. 2022-03-11
10.3390/biom12030436

Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism
Leyre Merino-Galan, Haritz Jimenez-Urbieta, Marta Zamarbide, Tatiana Rodríguez-Chinchilla, Arantzazu Belloso-Iguerategui, Enrique Santamaria, Joaquín Fernández-Irigoyen, Ana Aiastui, Evelyne Doudnikoff, Erwan Bézard, Alberto Ouro, Shira Knafo, Belén Gago, Ana Quiroga-Varela, María Cruz Rodríguez-Oroz
Brain. 2022-03-04
10.1093/brain/awac087

How Lazy Reading and Semantic Sloppiness May Harm Progress in Synucleinopathy Research
Erwan Bezard
Biomolecules. 2022-01-28
10.3390/biom12020228

Similar neuronal imprint and no cross-seeded fibrils in α-synuclein aggregates from MSA and Parkinson’s disease
Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas
npj Parkinsons Dis.. 2022-01-13
10.1038/s41531-021-00264-w

Maladie de Parkinson
Erwan Bezard, Benjamin Dehay
Med Sci (Paris). 2022-01-01
10.1051/medsci/2021241

Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?
Javier Blesa, Guglielmo Foffani, Benjamin Dehay, Erwan Bezard, Jose A. Obeso
Nat Rev Neurosci. 2021-12-14
10.1038/s41583-021-00542-9

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
Marie-Laure Arotcarena, Sandra Dovero, Nathalie Biendon, Nathalie Dutheil, Vincent Planche, Erwan Bezard, Benjamin Dehay
Front. Bioeng. Biotechnol.. 2021-11-15
10.3389/fbioe.2021.762209

Lack of limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment
Morgane Darricau, Marie-Hélène Canron, Marion Bosc, Marie-Laure Arotçarena, Mégane Le Quang, Benjamin Dehay, Erwan Bezard, Vincent Planche
Neurobiology of Aging. 2021-11-01
10.1016/j.neurobiolaging.2021.07.009

Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[18F]fluoro-L-m-tyrosine imaging and motor performances analysis.
Guillaume Becker, Anne Michel, Mohamed Ali Bahri, Georges Mairet-Coello, Christian Lemaire, Tania Deprez, Aline Freyssin, Lucas Jacquin, Fabian Hustadt, Catherine De Wolf, Mélina Caruso, Jean-Marie Frequin, Eric Gillent, Erwan Bezard, Gaetan Garraux, André Luxen, Martin Citron, Patrick Downey, Alain Plenevaux
Neurobiology of Aging. 2021-11-01
10.1016/j.neurobiolaging.2021.07.012

Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
Lauren Malave, Dustin R. Zuelke, Santiago Uribe-Cano, Lev Starikov, Heike Rebholz, Eitan Friedman, Chuan Qin, Qin Li, Erwan Bezard, Andreas H. Kottmann
Commun Biol. 2021-09-22
10.1038/s42003-021-02567-3

Impaired brain insulin signalling in Parkinson’s disease
Fares Bassil, Anna Delamarre, Marie‐Helene Canron, Nathalie Dutheil, Anne Vital, Marie‐Laure Négrier‐Leibreich, Erwan Bezard, Pierre‐Olivier Fernagut, Wassilios G. Meissner
Neuropathol Appl Neurobiol. 2021-08-17
10.1111/nan.12760

Similar neuronal imprint and absence of cross-seeded partner fibrils in α-synuclein aggregates from MSA and Parkinson’s disease brains
Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas
Preprint bioRxiv. 2021-06-22
10.1101/2021.06.22.449410

Adenosine A2AR/A1R Antagonists Enabling Additional H3R Antagonism for the Treatment of Parkinson's Disease.
Stefanie Hagenow, Anna Affini, Elsa Y. Pioli, Sonja Hinz, Yan Zhao, Gregory Porras, Vigneshwaran Namasivayam, Christa E. Müller, Jian-Sheng Lin, Erwan Bezard, Holger Stark
J. Med. Chem.. 2021-06-09
10.1021/acs.jmedchem.0c00914

Amyloid beta oligomers modulate neuronal autophagy through the primary cilium
Olatz Pampliega, Federico N. Soria, Narayana Pineda-Ramírez, Erwan Bezard
Preprint bioRxiv. 2021-06-02
10.1101/2021.06.02.446758

Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE
Xiuping Sun, Xuan Yu, Ling Zhang, Wenjie Zhao, Manshi Wang, Yu Zhang, Xianglei Li, Ran Gao, Ludivine S. Breger, Sandra Dovero, Gregory Porras, Pierre-Olivier Fernagut, Benjamin Dehay, Erwan Bezard, Chuan Qin
Heliyon. 2021-02-01
10.1016/j.heliyon.2021.e06302

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
J. W. Squair, M. Gautier, L. Mahe, J.E. Soriano, A Rowald, A. Bichat, N. Cho, M. A. Anderson, N. D. James, J. Gandar, A. V. Incognito, G. Schiavone, Z. K. Sarafis, A. Laskaratos, K. Bartholdi, R. Demesmaeker, S. Komi, C. Moerman, B. Vaseghi, B. Scott, R. Rosentreter, C. Kathe, J. Ravier, L. McCracken, X. Kang, N. Vachicouras, F. Fallegger, I. Jelescu, Y. Cheng, Q. Li, R. Buschman, N. Buse, T. Denison, S. Dukelow, R. Charbonneau, I. Rigby, S. K. Boyd, P.J. Millar, E. M. Moraud, M. Capogrosso, F. B. Wagner, Q. Barraud, E. Bezard, S. P. Lacour, J. Bloch, G. Courtine, A. A. Phillips
Nature. 2021-01-27
10.1038/s41586-020-03180-w

Involvement of Autophagy in Levodopa‐Induced Dyskinesia
Michael Feyder, Carina Plewnia, Ori J. Lieberman, Giada Spigolon, Alessandro Piccin, Lidia Urbina, Benjamin Dehay, Qin Li, Per Nilsson, Mikael Altun, Emanuela Santini, David Sulzer, Erwan Bezard, Anders Borgkvist, Gilberto Fisone
Mov Disord. 2021-01-18
10.1002/mds.28480

Mass spectrometry imaging identifies abnormally elevated brain l -DOPA levels and extrastriatal monoaminergic dysregulation in l -DOPA–induced dyskinesia
Elva Fridjonsdottir, Reza Shariatgorji, Anna Nilsson, Theodosia Vallianatou, Luke R. Odell, Luke S. Schembri, Per Svenningsson, Pierre-Olivier Fernagut, Alan R. Crossman, Erwan Bezard, Per E. Andrén
Sci. Adv.. 2021-01-06
10.1126/sciadv.abe5948

Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.
David J. Marmion, Angela A. Rutkowski, Diptaman Chatterjee, Benjamin M. Hiller, Milton H. Werner, Erwan Bezard, Deniz Kirik, Thomas McCown, Steven J. Gray, Jeffrey H. Kordower
Neurobiology of Disease. 2021-01-01
10.1016/j.nbd.2020.105184

Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia
Elva Fridjonsdottir, Reza Shariatgorji, Anna Nilsson, Theodosia Vallianatou, Luke R. Odell, Luke S. Schembri, Per Svenningsson, Pierre-Olivier Fernagut, Alan R. Crossman, Erwan Bezard, Per E. Andrén
Sci. Adv.. 2021-01-01
10.1126/sciadv.abe5948

Evaluation of blood flow as a route for propagation in experimental synucleinopathy
Xuan Yu, Marine Persillet, Ling Zhang, Yu Zhang, Sun Xiuping, Xianglei Li, Gao Ran, Ludivine S. Breger, Sandra Dovero, Gregory Porras, Benjamin Dehay, Erwan Bezard, Chuan Qin
Neurobiology of Disease. 2021-01-01
10.1016/j.nbd.2021.105255

L‐DOPA regulates α‐synuclein accumulation in experimental parkinsonism
Marc Deffains, Marie‐Hélène Canron, Margaux Teil, Qin Li, Benjamin Dehay, Erwan Bezard, Pierre‐Olivier Fernagut
Neuropathol Appl Neurobiol. 2020-12-04
10.1111/nan.12678

Gastrointestinal and metabolic function in the MPTP-treated macaque model of Parkinson's disease
Anna Delamarre, Cliona MacSweeney, Rie Suzuki, Alastair JH. Brown, Qin Li, Elsa Y. Pioli, Erwan Bezard
Heliyon. 2020-12-01
10.1016/j.heliyon.2020.e05771

From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease.
Tiago F. Outeiro, Peter Heutink, Erwan Bezard, Angela M. Cenci
Mov Disord. 2020-11-16
10.1002/mds.28387

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy
Florent Laferrière, Xin He, Federica Zinghirino, Evelyne Doudnikoff, Emilie Faggiani, Wassilios G. Meissner, Erwan Bezard, Francesca De Giorgi, François Ichas
Cells. 2020-10-29
10.3390/cells9112371

Corrigendum: Low-Dimensional Motor Cortex Dynamics Preserve Kinematics Information During Unconstrained Locomotion in Nonhuman Primates.
David Xing, Mehdi Aghagolzadeh, Wilson Truccolo, Erwan Bezard, Gregoire Courtine, David Borton
Front. Neurosci.. 2020-10-29
10.3389/fnins.2020.604517

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons
Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
Sci. Adv.. 2020-10-01
10.1126/sciadv.abc4364

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
Nora Bengoa-Vergniory, Emilie Faggiani, Paula Ramos-Gonzalez, Ecem Kirkiz, Natalie Connor-Robson, Liam V. Brown, Ibrar Siddique, Zizheng Li, Siv Vingill, Milena Cioroch, Fabio Cavaliere, Sarah Threlfell, Bradley Roberts, Thomas Schrader, Frank-Gerrit Klärner, Stephanie Cragg, Benjamin Dehay, Gal Bitan, Carlos Matute, Erwan Bezard, Richard Wade-Martins
Nat Commun. 2020-09-28
10.1038/s41467-020-18689-x

µ opioid receptor agonism for L-DOPA-induced dyskinesia in Parkinson’s disease
Erwan Bezard, Qin Li, Heather Hulme, Elva Fridjonsdottir, Anna Nilsson, Elsa Pioli, Per E. Andren, Alan R. Crossman
J. Neurosci.. 2020-07-20
10.1523/JNEUROSCI.0610-20.2020

Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
Federico N. Soria, Chiara Paviolo, Evelyne Doudnikoff, Marie-Laure Arotcarena, Antony Lee, Noémie Danné, Amit Kumar Mandal, Philippe Gosset, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezard
Nat Commun. 2020-07-10
10.1038/s41467-020-17328-9

Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson's disease.
Caroline Moreau, Anne Sophie Rolland, Elsa Pioli, Qin Li, Pascal Odou, Christine Barthelemy, Damien Lannoy, Alexandre Demailly, Natacha Carta, Vincent Deramecourt, Florent Auger, Gregory Kuchcinski, Charlotte Laloux, Luc Defebvre, Regis Bordet, James Duce, Jean Christophe Devedjian, Erwan Bezard, Matthieu Fisichella, David Devos
Neurobiology of Disease. 2020-06-01
10.1016/j.nbd.2020.104846

Ablation of the tail of the ventral tegmental area compensates symptoms in an experimental model of Parkinson's disease.
Fanny Faivre, María-José Sánchez-Catalán, Sandra Dovero, Simone Bido, Anil Joshi, Erwan Bezard, Michel Barrot
Neurobiology of Disease. 2020-06-01
10.1016/j.nbd.2020.104818

In vivo electrophysiological validation of DREADD-based modulation of pallidal neurons in the non-human primate.
Marc Deffains, Tho Haï Nguyen, Hugues Orignac, Nathalie Biendon, Sandra Dovero, Erwan Bezard, Thomas Boraud
Eur J Neurosci. 2020-05-11
10.1111/ejn.14746

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. T. Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard
Sci. Adv.. 2020-05-01
10.1126/sciadv.aaz9165

Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates
Philippe Gosset, Alexander Maxan, Melanie Alpaugh, Ludivine Breger, Benjamin Dehay, Zhu Tao, Zhang Ling, Chuan Qin, Giulia Cisbani, Nadia Fortin, Jean-Paul G. Vonsattel, Steve Lacroix, Abid Oueslati, Erwan Bezard, Francesca Cicchetti
Neurobiology of Disease. 2020-05-01
10.1016/j.nbd.2020.104941

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
Marie-Laure Arotcarena, Sandra Dovero, Alice Prigent, Mathieu Bourdenx, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Maddalena Tasselli, Philippe Aubert, Niels Kruse, Brit Mollenhauer, Ines Trigo Damas, Cristina Estrada, Nuria Garcia-Carrillo, Nishant N Vaikath, Omar M A El-Agnaf, Maria Trinidad Herrero, Miquel Vila, Jose A Obeso, Pascal Derkinderen, Benjamin Dehay, Erwan Bezard
Brain. 2020-05-01
10.1093/brain/awaa096

Use of adeno-associated virus-mediated delivery of mutant huntingtin to study the spreading capacity of the protein in mice and non-human primates
Alexander Maxan, Giacomo Sciacca, Melanie Alpaugh, Zhu Tao, Ludivine Breger, Benjamin Dehay, Zhang Ling, Chuan Qin, Giulia Cisbani, Maria Masnata, Shireen Salem, Steve Lacroix, Abid Oueslati, Erwan Bezard, Francesca Cicchetti
Neurobiology of Disease. 2020-05-01
10.1016/j.nbd.2020.104951

RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease.
Mehdi Eshraghi, Uri Nimrod Ramírez-Jarquín, Neelam Shahani, Tommaso Nuzzo, Arianna De Rosa, Supriya Swarnkar, Nicole Galli, Oscar Rivera, George Tsaprailis, Catherina Scharager-Tapia, Gogce Crynen, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Alessandro Usiello, Srinivasa Subramaniam
Sci. Adv.. 2020-05-01
10.1126/sciadv.aaz7001

Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy
Miguel Lopez-Cuina, Paul A. Guerin, Marie-Hélène Canron, Anna Delamarre, Benjamin Dehay, Erwan Bezard, Wassilios G. Meissner, Pierre-Olivier Fernagut
Mov Disord. 2020-04-14
10.1002/mds.28034

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy.
Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén
Neurobiology of Disease. 2020-04-01
10.1016/j.nbd.2020.104738

Soft, Implantable Bioelectronic Interfaces for Translational Research.
Giuseppe Schiavone, Florian Fallegger, Xiaoyang Kang, Beatrice Barra, Nicolas Vachicouras, Evgenia Roussinova, Ivan Furfaro, Sébastien Jiguet, Ismael Seáñez, Simon Borgognon, Andreas Rowald, Qin Li, Chuan Qin, Erwan Bézard, Jocelyne Bloch, Grégoire Courtine, Marco Capogrosso, Stéphanie P. Lacour
Adv. Mater.. 2020-03-16
10.1002/adma.201906512

Dopaminergic Co-transmission with Sonic Hedgehog Inhibits Expression of Abnormal Involuntary Movements
Lauren Malave, Dustin R. Zuelke, Lev Starikov, Heike Rebholz, Eitan Friedman, Chuan Qin, Qin Li, Erwan Bezard, Andreas H. Kottmann
. 2020-03-10
10.1101/2020.03.09.983759

Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons
Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
. 2020-02-12
10.1101/2020.02.11.943670

Corrigendum to "Dystonia and dopamine: From phenomenology to pathophysiology" [Prog. Neurobiol. 182 (November) (2019), 101678, 18].
Bastien Ribot, Jérome Aupy, Marie Vidailhet, Joachim Mazère, Antonio Pisani, Erwan Bezard, Dominique Guehl, Pierre Burbaud
Progress in Neurobiology. 2020-02-01
10.1016/j.pneurobio.2019.101745

Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice
Eléonore Bertin, Thomas Deluc, Kjara S. Pilch, Audrey Martinez, Johan-Till Pougnet, Evelyne Doudnikoff, Anne-Emilie Allain, Philine Bergmann, Marion Russeau, Estelle Toulmé, Erwan Bezard, Friedrich Koch-Nolte, Philippe Séguéla, Sabine Lévi, Bruno Bontempi, François Georges, Sandrine S. Bertrand, Olivier Nicole, Eric Boué-Grabot
Mol Psychiatry. 2020-01-08
10.1038/s41380-019-0641-8

Parkinsonian Symptoms, Not Dyskinesia, Negatively Affect Active Life Participation of Dyskinetic Patients with Parkinson's Disease.
Etienne Goubault, Sarah Bogard, Pierre J. Blanchet, Erwan Bézard, Claude Vincent, Davide Martino, Justyna Sarna, Oury Monchi, Christian Duval
Tremor and Other Hyperkinetic Movements. 2020-01-01
10.5334/tohm.403

Managing Parkinson's disease: moving ON with NOP.
Daniela Mercatelli, Erwan Bezard, Roberto Eleopra, Nurulain T. Zaveri, Michele Morari
Br J Pharmacol. 2020-01-01
10.1111/bph.14893

Models of hyperkinetic disorders in primates
Erwan Bezard
Journal of Neuroscience Methods. 2019-12-01
10.1016/j.jneumeth.2019.108551

Multiple System Atrophy: Recent Developments and Future Perspectives
Wassilios G. Meissner, Pierre‐Olivier Fernagut, Benjamin Dehay, Patrice Péran, Anne Pavy‐Le Traon, Alexandra Foubert‐Samier, Miguel Lopez Cuina, Erwan Bezard, François Tison, Olivier Rascol
Mov Disord. 2019-11-06
10.1002/mds.27894

Dystonia and dopamine: From phenomenology to pathophysiology
Bastien Ribot, Jérome Aupy, Marie Vidailhet, Joachim Mazère, Antonio Pisani, Erwan Bezard, Dominique Guehl, Pierre Burbaud
Progress in Neurobiology. 2019-11-01
10.1016/j.pneurobio.2019.101678

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. Trinidad Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard
. 2019-10-31
10.1101/825216

Comprehensive mapping of neurotransmitter networks by MALDI–MS imaging
Mohammadreza Shariatgorji, Anna Nilsson, Elva Fridjonsdottir, Theodosia Vallianatou, Patrik Källback, Luay Katan, Jonas Sävmarker, Ioannis Mantas, Xiaoqun Zhang, Erwan Bezard, Per Svenningsson, Luke R. Odell, Per E. Andrén
Nat Methods. 2019-09-23
10.1038/s41592-019-0551-3

Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard, Benjamin Dehay
JCI Insight. 2019-08-22
10.1172/jci.insight.129719

Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease.
Carl Rosenblad, Qin Li, Elsa Y. Pioli, Sandra Dovero, André SLM Antunes, Leticia Agúndez, Martino Bardelli, R. Michael Linden, Els Henckaerts, Anders Björklund, Erwan Bezard, Tomas Björklund
Brain. 2019-06-26
10.1093/brain/awz176

The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson's disease patients.
Tommaso Nuzzo, Daniela Punzo, Paola Devoto, Elena Rosini, Silvia Paciotti, Silvia Sacchi, Qin Li, Marie-Laure Thiolat, Celine Véga, Massimo Carella, Manolo Carta, Fabrizio Gardoni, Paolo Calabresi, Loredano Pollegioni, Erwan Bezard, Lucilla Parnetti, Francesco Errico, Alessandro Usiello
Sci Rep. 2019-06-20
10.1038/s41598-019-45419-1

Assessment of plasma creatine kinase as biomarker for levodopa-induced dyskinesia in Parkinson’s disease
Anna Delamarre, François Tison, Qin Li, Monique Galitzky, Olivier Rascol, Erwan Bezard, Wassilios G. Meissner
J Neural Transm. 2019-05-16
10.1007/s00702-019-02015-x

l-Dopa-free learned dyskinetic behavior in a Parkinson's primate model.
Qin Li, Pierre‐Olivier Fernagut, Erwan Bezard
Mov Disord. 2019-05-13
10.1002/mds.27715

Engrailed-1 induces long-lasting behavior benefit in an experimental Parkinson primate model.
Nitza Thomasson, Elsa Pioli, Claire Friedel, Arnaud Monseur, Jérémie Lavaur, Kenneth L. Moya, Erwan Bezard, Anne Bousseau, Alain Prochiantz
Mov Disord. 2019-05-11
10.1002/mds.27714

Remnants of Cardinal Symptoms of Parkinson's Disease, Not Dyskinesia, Are Problematic for Dyskinetic Patients Performing Activities of Daily Living.
Etienne Goubault, Hung P. Nguyen, Sarah Bogard, Pierre J. Blanchet, Erwan Bézard, Claude Vincent, Justyna Sarna, Oury Monchi, Christian Duval
Front. Neurol.. 2019-03-22
10.3389/fneur.2019.00256

Nanoscale exploration of the extracellular space in the live brain by combining single carbon nanotube tracking and super-resolution imaging analysis
Chiara Paviolo, Federico N. Soria, Joana S. Ferreira, Antony Lee, Laurent Groc, Erwan Bezard, Laurent Cognet
Methods. 2019-03-09
10.1016/j.ymeth.2019.03.005

Local transgene expression and whole-body transgenesis to model brain diseases in nonhuman primate
Lucie Chansel-Debordeaux, Erwan Bezard
Anim Models Exp Med. 2019-01-29
10.1002/ame2.12055

The hidden side of Parkinson's disease: studying pain, anxiety and depression in animal models.
Fanny Faivre, Anil Joshi, Erwan Bezard, Michel Barrot
Neuroscience & Biobehavioral Reviews. 2019-01-01
10.1016/j.neubiorev.2018.10.004

NMDA receptor GluN2D subunit participates to levodopa-induced dyskinesia pathophysiology
Manuela Mellone, Elisa Zianni, Jennifer Stanic, Federica Campanelli, Gioia Marino, Veronica Ghiglieri, Annalisa Longhi, Marie-Laure Thiolat, Qin Li, Paolo Calabresi, Erwan Bezard, Barbara Picconi, Monica Di Luca, Fabrizio Gardoni
Neurobiology of Disease. 2019-01-01
10.1016/j.nbd.2018.09.021

TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Florent Laferrière, Zuzanna Maniecka, Manuela Pérez-Berlanga, Marian Hruska-Plochan, Larissa Gilhespy, Eva-Maria Hock, Ulrich Wagner, Tariq Afroz, Paul J. Boersema, Gery Barmettler, Sandrine C. Foti, Yasmine T. Asi, Adrian M. Isaacs, Ashraf Al-Amoudi, Amanda Lewis, Henning Stahlberg, John Ravits, Francesca De Giorgi, François Ichas, Erwan Bezard, Paola Picotti, Tammaryn Lashley, Magdalini Polymenidou
Nat Neurosci. 2018-12-17
10.1038/s41593-018-0294-y

RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models.
Paola Bonsi, Giulia Ponterio, Valentina Vanni, Annalisa Tassone, Giuseppe Sciamanna, Sara Migliarini, Giuseppina Martella, Maria Meringolo, Benjamin Dehay, Evelyne Doudnikoff, Venetia Zachariou, Rose E Goodchild, Nicola B Mercuri, Marcello D'Amelio, Massimo Pasqualetti, Erwan Bezard, Antonio Pisani
EMBO Mol Med.. 2018-12-14
10.15252/emmm.201809283

Microdialysis in awake macaque monkeys for central nervous system pharmacokinetics
Thibaud Thiollier, Caisheng Wu, Gregory Porras, Erwan Bezard, Qin Li, Jinlan Zhang, Hugues Contamin
Anim Models Exp Med. 2018-12-01
10.1002/ame2.12046

G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice.
Salvatore Novello, Ludovico Arcuri, Sandra Dovero, Nathalie Dutheil, Derya R. Shimshek, Erwan Bezard, Michele Morari
Neurobiology of Disease. 2018-12-01
10.1016/j.nbd.2018.08.018

Levodopa-induced dyskinesia in Parkinson disease: Current and Evolving Concepts.
Alberto J. Espay, Francesca Morgante, Aristide Merola, Alfonso Fasano, Luca Marsili, Susan H. Fox, Erwan Bezard, Barbara Picconi, Paolo Calabresi, Anthony E. Lang
Ann Neurol.. 2018-11-30
10.1002/ana.25364

Harnessing Lysosomal pH through PLGA Nanoemulsion as a Treatment of Lysosomal-related Neurodegenerative Diseases.
Geoffrey Prévot, Federico N. Soria, Marie-Laure Thiolat, Jonathan Daniel, Jean Baptiste Verlhac, Mireille Blanchard-Desce, Erwan Bezard, Philippe Barthélémy, Sylvie Crauste-Manciet, Benjamin Dehay
Bioconjugate Chem.. 2018-11-13
10.1021/acs.bioconjchem.8b00697

The expression of cannabinoid type 1 receptor and 2-arachidonoyl glycerol synthesizing/degrading enzymes is altered in basal ganglia during the active phase of levodopa-induced dyskinesia.
Estefania Rojo-Bustamante, Miguel Angel Abellanas, Pedro Clavero, Marie-Laure Thiolat, Qin Li, Maria Rosario Luquin, Erwan Bezard, Maria S. Aymerich
Neurobiology of Disease. 2018-10-01
10.1016/j.nbd.2018.06.019

Meta-analysis of amantadine efficacy for improving preclinical research reliability.
Philip Stanley, Elsa Y. Pioli, Rouba Kozak, Michael Popiolek, Erwan Bezard
Mov Disord.. 2018-10-01
10.1002/mds.27486

An mGlu4-Positive Allosteric Modulator Alleviates Parkinsonism in Primates.
Delphine Charvin, Therese Di Paolo, Erwan Bezard, Laurent Gregoire, Akihiro Takano, Guillaume Duvey, Elsa Pioli, Christer Halldin, Rossella Medori, François Conquet
Mov Disord.. 2018-09-14
10.1002/mds.27462

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics
Marco Capogrosso, Fabien B. Wagner, Jerome Gandar, Eduardo Martin Moraud, Nikolaus Wenger, Tomislav Milekovic, Polina Shkorbatova, Natalia Pavlova, Pavel Musienko, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
Nat Protoc. 2018-09-01
10.1038/s41596-018-0030-9

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics.
Marco Capogrosso, Fabien B. Wagner, Jerome Gandar, Eduardo Martin Moraud, Nikolaus Wenger, Tomislav Milekovic, Polina Shkorbatova, Natalia Pavlova, Pavel Musienko, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
Nat Protoc. 2018-09-01
10.1038/s41596-018-0030-9

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.
Barry Boland, Wai Haung Yu, Olga Corti, Bertrand Mollereau, Alexandre Henriques, Erwan Bezard, Greg M. Pastores, David C. Rubinsztein, Ralph A. Nixon, Michael R. Duchen, Giovanna R. Mallucci, Guido Kroemer, Beth Levine, Eeva-Liisa Eskelinen, Fanny Mochel, Michael Spedding, Caroline Louis, Olivier R. Martin, Mark J. Millan
Nat Rev Drug Discov. 2018-08-17
10.1038/nrd.2018.109

Systemic Gene Delivery by Single-Dose Intracardiac Administration of scAAV2/9 and scAAV2/rh10 Variants in Newborn Rats.
Lucie Chansel-Debordeaux, Mathieu Bourdenx, Nathalie Dutheil, Sandra Dovero, Marie-Helene Canron, Clement Jimenez, Erwan Bezard, Benjamin Dehay
Human Gene Therapy Methods. 2018-08-01
10.1089/hgtb.2017.192.r3

Cardinal Motor Features of Parkinson's Disease Coexist with Peak-Dose Choreic-Type Drug-Induced Dyskinesia.
Etienne Goubault, Hung P. Nguyen, Sarah Bogard, Pierre J. Blanchet, Erwan Bézard, Claude Vincent, Mélanie Langlois, Christian Duval
JPD. 2018-06-13
10.3233/JPD-181312

Inhaling xenon ameliorates l-dopa-induced dyskinesia in experimental parkinsonism.
Jérôme Baufreton, Tomislav Milekovic, Qin Li, Steve McGuire, Eduardo Martin Moraud, Grégory Porras, Shiqi Sun, Wai Kin D. Ko, Marine Chazalon, Stéphanie Morin, Elisabeth Normand, Géraldine Farjot, Aude Milet, Jan Pype, Elsa Pioli, Gregoire Courtine, Baptiste Bessière, Erwan Bezard
Mov Disord.. 2018-05-14
10.1002/mds.27404

Inhaling xenon ameliorates l-dopa-induced dyskinesia in experimental parkinsonism
Jérôme Baufreton, Tomislav Milekovic, Qin Li, Steve McGuire, Eduardo Martin Moraud, Grégory Porras, Shiqi Sun, Wai Kin D. Ko, Marine Chazalon, Stéphanie Morin, Elisabeth Normand, Géraldine Farjot, Aude Milet, Jan Pype, Elsa Pioli, Gregoire Courtine, Baptiste Bessière, Erwan Bezard
Mov Disord.. 2018-05-14
10.1002/mds.27404

The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline.
David Castonguay, Julien Dufort-Gervais, Caroline Ménard, Manavi Chatterjee, Rémi Quirion, Bruno Bontempi, Jay S. Schneider, Amy F.T. Arnsten, Angus C. Nairn, Christopher M. Norris, Guylaine Ferland, Erwan Bézard, Pierrette Gaudreau, Paul J. Lombroso, Jonathan Brouillette
Current Biology. 2018-04-01
10.1016/j.cub.2018.02.047

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson's Disease Models.
Angelo Iannielli, Simone Bido, Lucrezia Folladori, Alice Segnali, Cinzia Cancellieri, Alessandra Maresca, Luca Massimino, Alicia Rubio, Giuseppe Morabito, Leonardo Caporali, Francesca Tagliavini, Olimpia Musumeci, Giuliana Gregato, Erwan Bezard, Valerio Carelli, Valeria Tiranti, Vania Broccoli
Cell Reports. 2018-02-01
10.1016/j.celrep.2018.01.089

Synaptic Regulator α-Synuclein in Dopaminergic Fibers Is Essentially Required for the Maintenance of Subependymal Neural Stem Cells
Ana Perez-Villalba, M. Salomé Sirerol-Piquer, Germán Belenguer, Raúl Soriano-Cantón, Ana Belén Muñoz-Manchado, Javier Villadiego, Diana Alarcón-Arís, Federico N. Soria, Benjamin Dehay, Erwan Bezard, Miquel Vila, Analía Bortolozzi, Juan José Toledo-Aral, Francisco Pérez-Sánchez, Isabel Fariñas
J. Neurosci.. 2017-12-07
10.1523/JNEUROSCI.2276-17.2017

Experimental animal models of Parkinson's disease: A transition from assessing symptomatology to α-synuclein targeted disease modification
Wai Kin D. Ko, Erwan Bezard
Experimental Neurology. 2017-12-01
10.1016/j.expneurol.2017.07.020

Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias.
Jennifer Stanic, Manuela Mellone, Francesco Napolitano, Claudia Racca, Elisa Zianni, Daiana Minocci, Veronica Ghiglieri, Marie-Laure Thiolat, Qin Li, Annalisa Longhi, Arianna De Rosa, Barbara Picconi, Erwan Bezard, Paolo Calabresi, Monica Di Luca, Alessandro Usiello, Fabrizio Gardoni
Neurobiology of Disease. 2017-12-01
10.1016/j.nbd.2017.08.001

In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson's disease.
L Chansel-Debordeaux, M Bourdenx, S Dovero, V Grouthier, N Dutheil, A Espana, L Groc, C Jimenez, E Bezard, B Dehay
Gene Ther. 2017-11-16
10.1038/gt.2017.84

A preclinical study on the combined effects of repeated eltoprazine and preladenant treatment for alleviating L-DOPA-induced dyskinesia in Parkinson's disease.
Wai Kin D. Ko, Qin Li, Long Yun Cheng, Micaela Morelli, Manolo Carta, Erwan Bezard
European Journal of Pharmacology. 2017-10-01
10.1016/j.ejphar.2017.07.030

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy.
J.A. Obeso, M. Stamelou, C.G. Goetz, W. Poewe, A.E. Lang, D. Weintraub, D. Burn, G.M. Halliday, E. Bezard, S. Przedborski, S. Lehericy, D.J. Brooks, J.C. Rothwell, M. Hallett, M.R. DeLong, C. Marras, C.M. Tanner, G.W. Ross, J.W. Langston, C. Klein, V. Bonifati, J. Jankovic, A.M. Lozano, G. Deuschl, H. Bergman, E. Tolosa, M. Rodriguez-Violante, S. Fahn, R.B. Postuma, D. Berg, K. Marek, D.G. Standaert, D.J. Surmeier, C.W. Olanow, J.H. Kordower, P. Calabresi, A.H.V. Schapira, A.J. Stoessl
Mov Disord.. 2017-09-01
10.1002/mds.27115

Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson’s disease
Simone Bido, Federico N. Soria, Rebecca Z. Fan, Erwan Bezard, Kim Tieu
Sci Rep. 2017-08-08
10.1038/s41598-017-07181-0

Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies
Mathieu Bourdenx, Nikolaos Stavros Koulakiotis, Despina Sanoudou, Erwan Bezard, Benjamin Dehay, Anthony Tsarbopoulos
Progress in Neurobiology. 2017-08-01
10.1016/j.pneurobio.2015.07.003

Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques.
Francesco Napolitano, Emily Booth Warren, Sara Migliarini, Daniela Punzo, Francesco Errico, Qin Li, Marie-Laure Thiolat, Angelo Luigi Vescovi, Paolo Calabresi, Erwan Bezard, Micaela Morelli, Christine Konradi, Massimo Pasqualetti, Alessandro Usiello
PLoS ONE. 2017-07-25
10.1371/journal.pone.0181677

Alterations in functional cortical hierarchy in hemiparkinsonian rats.
Borbála Nóra Jávor-Duray, Martin Vinck, Marcel van der Roest, Erwan Bezard, Henk W. Berendse, Thomas Boraud, Pieter Voorn
J. Neurosci.. 2017-07-07
10.1523/jneurosci.3257-16.2017

In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains.
Fabio Cavaliere, Loic Cerf, Benjamin Dehay, Paula Ramos-Gonzalez, Francesca De Giorgi, Mathieu Bourdenx, Alban Bessede, Jose A. Obeso, Carlos Matute, François Ichas, Erwan Bezard
Neurobiology of Disease. 2017-07-01
10.1016/j.nbd.2017.04.011

U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells
Mathieu Schmitt, Benjamin Dehay, Erwan Bezard, F. Javier Garcia-Ladona
Synapse. 2017-06-20
10.1002/syn.21980

Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.
Fares Bassil, Paul A. Guerin, Nathalie Dutheil, Qin Li, Matthias Klugmann, Wassilios G. Meissner, Erwan Bezard, Pierre-Olivier Fernagut
Mov Disord.. 2017-05-29
10.1002/mds.27041

Involvement of the bed nucleus of the stria terminalis in L-Dopa induced dyskinesia
Matthieu F. Bastide, Christelle Glangetas, Evelyne Doudnikoff, Qin Li, Mathieu Bourdenx, Pierre-Olivier Fernagut, Éric C. Dumont, François Georges, Erwan Bézard
Sci Rep. 2017-05-24
10.1038/s41598-017-02572-9

Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration.
Federico N. Soria, Michel Engeln, Marta Martinez-Vicente, Christelle Glangetas, María José López-González, Sandra Dovero, Benjamin Dehay, Elisabeth Normand, Miquel Vila, Alexandre Favereaux, François Georges, Christophe Lo Bianco, Erwan Bezard, Pierre-Olivier Fernagut
Human Molecular Genetics. 2017-05-17
10.1093/hmg/ddx120

Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.
Mathieu Bourdenx, Sandra Dovero, Marie-Laure Thiolat, Erwan Bezard, Benjamin Dehay
Sci Rep. 2017-04-04
10.1038/srep45831

Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate.
Anna Migdalska-Richards, Wai Kin D. Ko, Qin Li, Erwan Bezard, Anthony H. V. Schapira
Synapse. 2017-03-17
10.1002/syn.21967

Insulin resistance and exendin-4 treatment for multiple system atrophy.
Fares Bassil, Marie-Hélène Canron, Anne Vital, Erwan Bezard, Yazhou Li, Nigel H Greig, Seema Gulyani, Dimitrios Kapogiannis, Pierre-Olivier Fernagut, Wassilios G Meissner
Brain. 2017-03-14
10.1093/brain/awx044

Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update.
Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut
The Lancet Neurology. 2017-03-01
10.1016/s1474-4422(17)30004-2

Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update.
Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut
The Lancet Neurology. 2017-03-01
10.1016/s1474-4422(17)30004-2

Exosomes, an Unmasked Culprit in Neurodegenerative Diseases.
Federico N. Soria, Olatz Pampliega, Mathieu Bourdenx, Wassilios G. Meissner, Erwan Bezard, Benjamin Dehay
Front. Neurosci.. 2017-01-31
10.3389/fnins.2017.00026

Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity.
Daniel Ysselstein, Benjamin Dehay, Isabel M. Costantino, George P. McCabe, Matthew P. Frosch, Julia M. George, Erwan Bezard, Jean-Christophe Rochet
acta neuropathol commun. 2017-01-10
10.1186/s40478-016-0403-7

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.
Anna Migdalska-Richards, Liam Daly, Erwan Bezard, Anthony H. V. Schapira
Ann Neurol.. 2016-11-01
10.1002/ana.24790

An evaluation of istradefylline treatment on Parkinsonian motor and cognitive deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque models
Wai Kin D. Ko, Sandrine M. Camus, Qin Li, Jianzhong Yang, Steve McGuire, Elsa Y. Pioli, Erwan Bezard
Neuropharmacology. 2016-11-01
10.1016/j.neuropharm.2016.07.012

A brain-spine interface alleviating gait deficits after spinal cord injury in primates.
Marco Capogrosso, Tomislav Milekovic, David Borton, Fabien Wagner, Eduardo Martin Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jerome Gandar, Quentin Barraud, David Xing, Elodie Rey, Simone Duis, Yang Jianzhong, Wai Kin D. Ko, Qin Li, Peter Detemple, Tim Denison, Silvestro Micera, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
Nature. 2016-11
10.1038/nature20118

Multi-facetted impulsivity following nigral degeneration and dopamine replacement therapy.
Michel Engeln, Solène Ansquer, Emilie Dugast, Erwan Bezard, David Belin, Pierre-Olivier Fernagut
Neuropharmacology. 2016-10-01
10.1016/j.neuropharm.2016.05.013

LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.
René Fuertig, Angelo Ceci, Sandrine M Camus, Erwan Bezard, Andreas H Luippold, Bastian Hengerer
Bioanalysis. 2016-09-01
10.4155/bio-2016-0111

Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.
Fares Bassil, Pierre-Olivier Fernagut, Erwan Bezard, Alain Pruvost, Thierry Leste-Lasserre, Quyen Q. Hoang, Dagmar Ringe, Gregory A. Petsko, Wassilios G. Meissner
Proc Natl Acad Sci USA. 2016-08-01
10.1073/pnas.1609291113

Is near-infrared light neuroprotective?
Erwan Bezard
Ann Neurol.. 2016-06-24
10.1002/ana.24698

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.
Weixing Shen, Joshua L. Plotkin, Veronica Francardo, Wai Kin D. Ko, Zhong Xie, Qin Li, Tim Fieblinger, Jürgen Wess, Richard R. Neubig, Craig W. Lindsley, P. Jeffrey Conn, Paul Greengard, Erwan Bezard, M. Angela Cenci, D. James Surmeier
Neuron. 2016-06-01
10.1016/j.neuron.2016.05.017

MitoBrain, Putting energy into the brain.
Giovanni Benard, Erwan Bezard, Giovanni Marsicano, Sandrine Pouvreau
Neurobiology of Disease. 2016-06-01
10.1016/j.nbd.2016.03.021

A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.
François Tison, Charlotte Keywood, Mark Wakefield, Franck Durif, Jean-Christophe Corvol, Karla Eggert, Mark Lew, Stuart Isaacson, Erwan Bezard, Sonia-Maria Poli, Christopher G. Goetz, Claudia Trenkwalder, Olivier Rascol
Mov Disord.. 2016-05-23
10.1002/mds.26659

Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease.
Ludovico Arcuri, Riccardo Viaro, Simone Bido, Francesco Longo, Mariangela Calcagno, Pierre-Olivier Fernagut, Nurulain T. Zaveri, Girolamo Calò, Erwan Bezard, Michele Morari
Neurobiology of Disease. 2016-05-01
10.1016/j.nbd.2016.01.016

Permeability of blood-brain barrier in macaque model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson disease.
Thibaud Thiollier, Caisheng Wu, Hugues Contamin, Qin Li, Jinlan Zhang, Erwan Bezard
Synapse. 2016-03-15
10.1002/syn.21889

Selective Inactivation of Striatal FosB/ΔFosB-Expressing Neurons Alleviates L-DOPA-Induced Dyskinesia.
Michel Engeln, Matthieu F. Bastide, Estelle Toulmé, Benjamin Dehay, Mathieu Bourdenx, Evelyne Doudnikoff, Qin Li, Christian E. Gross, Eric Boué-Grabot, Antonio Pisani, Erwan Bezard, Pierre-Olivier Fernagut
Biological Psychiatry. 2016-03-01
10.1016/j.biopsych.2014.07.007

Targeting α-synuclein: Therapeutic options.
Benjamin Dehay, Mickael Decressac, Mathieu Bourdenx, Irene Guadagnino, Pierre-Olivier Fernagut, Anna Tamburrino, Fares Bassil, Wassilios G. Meissner, Erwan Bezard
Mov Disord.. 2016-03-01
10.1002/mds.26568

Inhibiting Lateral Habenula Improves L-DOPA-Induced Dyskinesia.
Matthieu F. Bastide, Brice de la Crompe, Evelyne Doudnikoff, Pierre-Olivier Fernagut, Christian E. Gross, Nicolas Mallet, Thomas Boraud, Erwan Bézard
Biological Psychiatry. 2016-03-01
10.1016/j.biopsych.2014.08.022

Antidyskinetic effect of A2A and 5HT1A/1B receptor ligands in two animal models of Parkinson's disease.
Annalisa Pinna, Wai Kin D. Ko, Giulia Costa, Elisabetta Tronci, Camino Fidalgo, Nicola Simola, Qin Li, Mojgan Aghazadeh Tabrizi, Erwan Bezard, Manolo Carta, Micaela Morelli
Mov Disord.. 2016-02-12
10.1002/mds.26475

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury.
Nikolaus Wenger, Eduardo Martin Moraud, Jerome Gandar, Pavel Musienko, Marco Capogrosso, Laetitia Baud, Camille G Le Goff, Quentin Barraud, Natalia Pavlova, Nadia Dominici, Ivan R Minev, Leonie Asboth, Arthur Hirsch, Simone Duis, Julie Kreider, Andrea Mortera, Oliver Haverbeck, Silvio Kraus, Felix Schmitz, Jack DiGiovanna, Rubia van den Brand, Jocelyne Bloch, Peter Detemple, Stéphanie P Lacour, Erwan Bézard, Silvestro Micera, Grégoire Courtine
Nat Med. 2016-01-18
10.1038/nm.4025

Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases.
Mathieu Bourdenx, Jonathan Daniel, Emilie Genin, Federico N. Soria, Mireille Blanchard-Desce, Erwan Bezard, Benjamin Dehay
Autophagy. 2016-01-13
10.1080/15548627.2015.1136769

Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line.
Mathieu Schmitt, Benjamin Dehay, Erwan Bezard, F. Javier Garcia-Ladona
Synapse. 2016-01-06
10.1002/syn.21881

Striatal NELF-mediated RNA polymerase II stalling controls L-dopa induced dyskinesia.
Matthieu F. Bastide, Simone Bido, Nathalie Duteil, Erwan Bézard
Neurobiology of Disease. 2016-01-01
10.1016/j.nbd.2015.10.013

Early prenatal exposure to MPTP does not affect nigrostrial neurons in macaque monkey.
Mathieu Bourdenx, Sandra Dovero, Philippe De DeurwAerdère, Qin Li, Erwan Bezard
Synapse. 2015-12-04
10.1002/syn.21876

Unexpected toxicity of very low dose MPTP in mice: A clue to the etiology of Parkinson's disease?
Sandra Dovero, Christian Gross, Erwan Bezard
Synapse. 2015-12-01
10.1002/syn.21875

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.
Weixing Shen, Joshua L. Plotkin, Veronica Francardo, Wai Kin D. Ko, Zhong Xie, Qin Li, Tim Fieblinger, Jürgen Wess, Richard R. Neubig, Craig W. Lindsley, P. Jeffrey Conn, Paul Greengard, Erwan Bezard, M. Angela Cenci, D. James Surmeier
Neuron. 2015-11-01
10.1016/j.neuron.2015.10.039

Why bother using non-human primate models of cognitive disorders in translational research?
Sandrine Camus, Wai Kin D. Ko, Elsa Pioli, Erwan Bezard
Neurobiology of Learning and Memory. 2015-10-01
10.1016/j.nlm.2015.06.012

Alpha-synuclein propagation: New insights from animal models.
Benjamin Dehay, Miquel Vila, Erwan Bezard, Patrik Brundin, Jeffrey H. Kordower
Mov Disord.. 2015-09-08
10.1002/mds.26370

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.
Matthieu F. Bastide, Wassilios G. Meissner, Barbara Picconi, Stefania Fasano, Pierre-Olivier Fernagut, Michael Feyder, Veronica Francardo, Cristina Alcacer, Yunmin Ding, Riccardo Brambilla, Gilberto Fisone, A. Jon Stoessl, Mathieu Bourdenx, Michel Engeln, Sylvia Navailles, Philippe De Deurwaerdère, Wai Kin D. Ko, Nicola Simola, Micaela Morelli, Laurent Groc, Maria-Cruz Rodriguez, Eugenia V. Gurevich, Maryka Quik, Michele Morari, Manuela Mellone, Fabrizio Gardoni, Elisabetta Tronci, Dominique Guehl, François Tison, Alan R. Crossman, Un Jung Kang, Kathy Steece-Collier, Susan Fox, Manolo Carta, M. Angela Cenci, Erwan Bézard
Progress in Neurobiology. 2015-09-01
10.1016/j.pneurobio.2015.07.002

Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates.
Lucia Friedli, Ephron S. Rosenzweig, Quentin Barraud, Martin Schubert, Nadia Dominici, Lea Awai, Jessica L. Nielson, Pavel Musienko, Yvette Nout-Lomas, Hui Zhong, Sharon Zdunowski, Roland R. Roy, Sarah C. Strand, Rubia van den Brand, Leif A. Havton, Michael S. Beattie, Jacqueline C. Bresnahan, Erwan Bézard, Jocelyne Bloch, V. Reggie Edgerton, Adam R. Ferguson, Armin Curt, Mark H. Tuszynski, Grégoire Courtine
Sci. Transl. Med.. 2015-08-26
10.1126/scitranslmed.aac5811

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.
Benjamin Dehay, Mathieu Bourdenx, Philippe Gorry, Serge Przedborski, Miquel Vila, Stéphane Hunot, Andrew Singleton, C Warren Olanow, Kalpana M Merchant, Erwan Bezard, Gregory A Petsko, Wassilios G Meissner
The Lancet Neurology. 2015-08-01
10.1016/s1474-4422(15)00006-x

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.
Mathieu Bourdenx, Sandra Dovero, Michel Engeln, Simone Bido, Matthieu F. Bastide, Nathalie Dutheil, Isabel Vollenweider, Laetitia Baud, Camille Piron, Virginie Grouthier, Thomas Boraud, Grégory Porras, Qin Li, Veerle Baekelandt, Dieter Scheller, Anne Michel, Pierre-Olivier Fernagut, François Georges, Grégoire Courtine, Erwan Bezard, Benjamin Dehay
acta neuropathol commun. 2015-07-25
10.1186/s40478-015-0222-2

Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson’s disease
C. Fidalgo, W.K.D. Ko, E. Tronci, Q. Li, R. Stancampiano, Q. Chuan, E. Bezard, M. Carta
Neuroscience. 2015-07-01
10.1016/j.neuroscience.2015.04.027

D1 dopamine receptor stimulation impairs striatal proteasome activity in Parkinsonism through 26S proteasome disassembly.
Pedro Barroso-Chinea, Marie-Laure Thiolat, Simone Bido, Audrey Martinez, Evelyne Doudnikoff, Jérôme Baufreton, Mathieu Bourdenx, Bertrand Bloch, Erwan Bezard, Marie-Laure Martin-Negrier
Neurobiology of Disease. 2015-06-01
10.1016/j.nbd.2015.02.024

Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.
Nikhil M. Urs, Simone Bido, Sean M. Peterson, Tanya L. Daigle, Caroline E. Bass, Raul R. Gainetdinov, Erwan Bezard, Marc G. Caron
Proc Natl Acad Sci USA. 2015-04-27
10.1073/pnas.1502740112

Blood withdrawal affects iron store dynamics in primates with consequences on monoaminergic system function.
C. Hyacinthe, P. De Deurwaerdere, T. Thiollier, Q. Li, E. Bezard, I. Ghorayeb
Neuroscience. 2015-04-01
10.1016/j.neuroscience.2015.01.057

Could the serotonin theory give rise to a treatment for levodopa-induced dyskinesia in Parkinson's disease?
Erwan Bezard, Manolo Carta
Brain. 2015-02-05
10.1093/brain/awu407

Wireless neurosensor for full-spectrum electrophysiology recordings during free behavior.
Ming Yin, David A. Borton, Jacob Komar, Naubahar Agha, Yao Lu, Hao Li, Jean Laurens, Yiran Lang, Qin Li, Christopher Bull, Lawrence Larson, David Rosler, Erwan Bezard, Grégoire Courtine, Arto V. Nurmikko
Neuron. 2014-12-01
10.1016/j.neuron.2014.11.010

Direct targeted quantitative molecular imaging of neurotransmitters in brain tissue sections.
Mohammadreza Shariatgorji, Anna Nilsson, Richard J.A. Goodwin, Patrik Källback, Nicoletta Schintu, Xiaoqun Zhang, Alan R. Crossman, Erwan Bezard, Per Svenningsson, Per E. Andren
Neuron. 2014-11-01
10.1016/j.neuron.2014.10.011

RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease.
Wai Kin D. Ko, Marie-Laure Martin-Negrier, Erwan Bezard, Alan R. Crossman, Paula Ravenscroft
Neurobiology of Disease. 2014-10-01
10.1016/j.nbd.2014.06.013

Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?
Giselle Charron, Evelyne Doudnikoff, Marie-Helene Canron, Qin Li, Céline Véga, Sebastien Marais, Jérôme Baufreton, Anne Vital, Stéphane H. R. Oliet, Erwan Bezard
Front. Aging Neurosci.. 2014-09-24
10.3389/fnagi.2014.00258

Down-regulating α-synuclein for treating synucleopathies.
Mathieu Bourdenx, Benjamin Dehay, Erwan Bezard
Mov Disord.. 2014-09-12
10.1002/mds.26028

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.
Mathieu Bourdenx, Erwan Bezard, Benjamin Dehay
Front. Neuroanat.. 2014-08-14
10.3389/fnana.2014.00083

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives.
Anthony H V Schapira, C Warren Olanow, J Timothy Greenamyre, Erwan Bezard
The Lancet. 2014-08-01
10.1016/s0140-6736(14)61010-2

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives.
Anthony H V Schapira, C Warren Olanow, J Timothy Greenamyre, Erwan Bezard
The Lancet. 2014-08-01
10.1016/s0140-6736(14)61010-2

Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?
Fares Bassil, Pierre-Olivier Fernagut, Erwan Bezard, Wassilios G. Meissner
Progress in Neurobiology. 2014-07-01
10.1016/j.pneurobio.2014.02.005

Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies.
Pierre-Olivier Fernagut, Benjamin Dehay, Aline Maillard, Erwan Bezard, Paul Perez, Anne Pavy-Le Traon, Olivier Rascol, Alexandra Foubert-Samier, François Tison, Wassilios G. Meissner
Neurobiology of Disease. 2014-07-01
10.1016/j.nbd.2014.03.021

Systemic gene delivery to the central nervous system using Adeno-associated virus.
Mathieu Bourdenx, Nathalie Dutheil, Erwan Bezard, Benjamin Dehay
Front. Mol. Neurosci.. 2014-06-02
10.3389/fnmol.2014.00050

The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.
Erwan Bezard, Elsa Y. Pioli, Qin Li, Françoise Girard, Vincent Mutel, Charlotte Keywood, Francois Tison, Olivier Rascol, Sonia M. Poli
Mov Disord.. 2014-05-27
10.1002/mds.25920

Widespread Monoaminergic Dysregulation of Both Motor and Non-Motor Circuits in Parkinsonism and Dyskinesia.
Michel Engeln, Philippe De Deurwaerdère, Qin Li, Erwan Bezard, Pierre-Olivier Fernagut
Cereb. Cortex. 2014-04-25
10.1093/cercor/bhu076

Effects of L-tryptophan on L-DOPA-induced dyskinesia in the L-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque model of Parkinson's disease.
Wai Kin D. Ko, Qin Li, Erwan Bezard
Neuroscience Letters. 2014-04-01
10.1016/j.neulet.2014.02.027

Combined fenobam and amantadine treatment promotes robust antidyskinetic effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primate model of Parkinson's disease.
Wai Kin D. Ko, Elsa Pioli, Qin Li, Steve McGuire, Audrey Dufour, Todd B. Sherer, Erwan Bezard, Maurizio F. Facheris
Mov Disord.. 2014-03-07
10.1002/mds.25859

D1 receptor agonist improves sleep-wake parameters in experimental parkinsonism.
Carole Hyacinthe, Quentin Barraud, François Tison, Erwan Bezard, Imad Ghorayeb
Neurobiology of Disease. 2014-03-01
10.1016/j.nbd.2013.10.029

Intra-axonal protein aggregation in the peripheral nervous system.
Anne Vital, Wassillios G. Meissner, Marie-Hélène Canron, Marie-Laure Martin-Negrier, Erwan Bezard, François Tison, Claude Vital
J Peripher Nerv Syst. 2014-03-01
10.1111/jns5.12056

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.
Ariadna Recasens, Benjamin Dehay, Jordi Bové, Iria Carballo-Carbajal, Sandra Dovero, Ana Pérez-Villalba, Pierre-Olivier Fernagut, Javier Blesa, Annabelle Parent, Celine Perier, Isabel Fariñas, José A. Obeso, Erwan Bezard, Miquel Vila
Ann Neurol.. 2014-02-18
10.1002/ana.24066

Abnormal structure-specific peptide transmission and processing in a primate model of Parkinson's disease and l-DOPA-induced dyskinesia.
Mathieu Bourdenx, Anna Nilsson, Henrik Wadensten, Maria Fälth, Qin Li, Alan R. Crossman, Per E. Andrén, Erwan Bezard
Neurobiology of Disease. 2014-02-01
10.1016/j.nbd.2013.10.016

Immediate-early gene expression in structures outside the basal ganglia is associated to l-DOPA-induced dyskinesia.
Matthieu F. Bastide, Sandra Dovero, Giselle Charron, Gregory Porras, Christian E. Gross, Pierre-Olivier Fernagut, Erwan Bézard
Neurobiology of Disease. 2014-02-01
10.1016/j.nbd.2013.09.020

L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum.
Gregory Porras, Philippe De Deurwaerdere, Qin Li, Matteo Marti, Rudolf Morgenstern, Reinhard Sohr, Erwan Bezard, Michele Morari, Wassilios G. Meissner
Sci Rep. 2014-01-16
10.1038/srep03730

Neurological drug development: a guide for a start-up biotech.
Thomas P. Blackburn, Erwan Bezard
Neurobiology of Disease. 2014-01-01
10.1016/j.nbd.2013.08.004

Premotor parkinsonism models.
Erwan Bezard, Pierre-Olivier Fernagut
Parkinsonism & Related Disorders. 2014-01-01
10.1016/s1353-8020(13)70007-5

Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: a species comparison.
Sandrine M. J. Camus, Céline Rochais, Catherine Blois-Heulin, Qin Li, Martine Hausberger, Erwan Bezard
Front. Behav. Neurosci.. 2014-01-01
10.3389/fnbeh.2014.00047

Premotor parkinsonism models.
Erwan Bezard, Pierre-Olivier Fernagut
Parkinsonism & Related Disorders. 2014-01-01
10.1016/s1353-8020(13)70007-5

Anti-dyskinetic effect of anpirtoline in animal models of L-DOPA-induced dyskinesia.
Erwan Bézard, Ana Muñoz, Elisabetta Tronci, Elsa Y. Pioli, Qin Li, Gregory Porras, Anders Björklund, Manolo Carta
Neuroscience Research. 2013-12-01
10.1016/j.neures.2013.10.002

Single-molecule imaging of the functional crosstalk between surface NMDA and dopamine D1 receptors.
L. Ladepeche, J. P. Dupuis, D. Bouchet, E. Doudnikoff, L. Yang, Y. Campagne, E. Bezard, E. Hosy, L. Groc
Proceedings of the National Academy of Sciences. 2013-10-14
10.1073/pnas.1310145110

Viral vectors in primate research: Examples from Parkinson’s disease research
Grégory Porras, Benjamin Dehay, Erwan Bezard
Neuromethods. 2013-09-19
10.1007/978-1-62703-610-8_17

D1 dopamine receptor-mediated LTP at GABA synapses encodes motivation to self-administer cocaine in rats.
M. Krawczyk, X. Mason, J. DeBacker, R. Sharma, C. P. Normandeau, E. R. Hawken, C. Di Prospero, C. Chiang, A. Martinez, A. A. Jones, E. Doudnikoff, S. Caille, E. Bezard, F. Georges, E. C. Dumont
Journal of Neuroscience. 2013-07-17
10.1523/jneurosci.1784-13.2013

Birth origin differentially affects depressive-like behaviours: are captive-born cynomolgus monkeys more vulnerable to depression than their wild-born counterparts?
Sandrine MJ. Camus, Céline Rochais, Catherine Blois-Heulin, Qin Li, Martine Hausberger, Erwan Bezard
PLoS ONE. 2013-07-04
10.1371/journal.pone.0067711

Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.
Michel Engeln, Stefania Fasano, Serge H. Ahmed, Martine Cador, Veerle Baekelandt, Erwan Bezard, Pierre-Olivier Fernagut
Ann Neurol.. 2013-07-01
10.1002/ana.23881

Levodopa-induced dyskinesias in the absence of nigrostriatal degeneration.
Erwan Bézard, C. Warren Olanow, José A. Obeso
Mov Disord.. 2013-06-20
10.1002/mds.25533

Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
Sandrine M. J. Camus, Catherine Blois-Heulin, Qin Li, Martine Hausberger, Erwan Bezard
PLoS ONE. 2013-04-29
10.1371/journal.pone.0062141

Lysosomal impairment in Parkinson's disease.
Benjamin Dehay, Marta Martinez-Vicente, Guy A. Caldwell, Kim A. Caldwell, Zhenyue Yue, Mark R. Cookson, Christine Klein, Miquel Vila, Erwan Bezard
Mov Disord.. 2013-04-11
10.1002/mds.25462

Effects of memantine and galantamine on cognitive performance in aged rhesus macaques.
Jay S. Schneider, Elsa Y. Pioli, Yang Jianzhong, Qin Li, Erwan Bezard
Neurobiology of Aging. 2013-04-01
10.1016/j.neurobiolaging.2012.10.020

Simvastatin decreases levodopa-induced dyskinesia in monkeys, but not in a randomized, placebo-controlled, multiple cross-over ("n-of-1") exploratory trial of simvastatin against levodopa-induced dyskinesia in Parkinson's disease patients.
François Tison, Laurence Nègre-Pagès, Wassilios G. Meissner, Sandrine Dupouy, Qin Li, Marie-Laure Thiolat, Thibaud Thiollier, Monique Galitzky, Fabienne Ory-Magne, Agathe Milhet, Laurent Marquine, Umberto Spampinato, Olivier Rascol, Erwan Bezard
Parkinsonism & Related Disorders. 2013-04-01
10.1016/j.parkreldis.2012.12.003

Study of the antidyskinetic effect of eltoprazine in animal models of levodopa-induced dyskinesia.
Erwan Bezard, Elisabetta Tronci, Elsa Y. Pioli, Qin Li, Gregory Porras, Anders Björklund, Manolo Carta
Mov Disord.. 2013-02-06
10.1002/mds.25366

[PSD-95 expression controls L-Dopa dyskinesia].
Matthieu Bastide, Erwan Bézard
Med Sci (Paris). 2013-02-01
10.1051/medsci/2013292008

Reinforcing properties of Pramipexole in normal and parkinsonian rats.
Michel Engeln, Serge H. Ahmed, Caroline Vouillac, François Tison, Erwan Bezard, Pierre-Olivier Fernagut
Neurobiology of Disease. 2013-01-01
10.1016/j.nbd.2012.08.005

Levodopa improves motor deficits but can further disrupt cognition in a macaque Parkinson model.
Jay S. Schneider, Elsa Y. Pioli, Yang Jianzhong, Qin Li, Erwan Bezard
Mov Disord.. 2012-12-12
10.1002/mds.25258

Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.
Marie-Hélène Canron, Martine Perret, Anne Vital, Erwan Bézard, Benjamin Dehay
Sci Rep. 2012-11-30
10.1038/srep00910

Nociceptin/orphanin FQ receptor agonists attenuate L-DOPA-induced dyskinesias.
M. Marti, D. Rodi, Q. Li, R. Guerrini, S. Fasano, I. Morella, A. Tozzi, R. Brambilla, P. Calabresi, M. Simonato, E. Bezard, M. Morari
Journal of Neuroscience. 2012-11-14
10.1523/jneurosci.6408-11.2012

Nociceptin/orphanin FQ receptor agonists attenuate L-DOPA-induced dyskinesias.
M. Marti, D. Rodi, Q. Li, R. Guerrini, S. Fasano, I. Morella, A. Tozzi, R. Brambilla, P. Calabresi, M. Simonato, E. Bezard, M. Morari
Journal of Neuroscience. 2012-11-14
10.1523/jneurosci.6408-11.2012

Experimental reappraisal of continuous dopaminergic stimulation against L-dopa-induced dyskinesia.
Erwan Bezard
Mov Disord.. 2012-11-09
10.1002/mds.25251

Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
Peter A. Tass, Li Qin, Christian Hauptmann, Sandra Dovero, Erwan Bezard, Thomas Boraud, Wassilios G. Meissner
Ann Neurol.. 2012-11-01
10.1002/ana.23663

Altered pallido-pallidal synaptic transmission leads to aberrant firing of globus pallidus neurons in a rat model of Parkinson's disease.
Cristina Miguelez, Stéphanie Morin, Audrey Martinez, Michel Goillandeau, Erwan Bezard, Bernard Bioulac, Jérôme Baufreton
The Journal of Physiology. 2012-09-25
10.1113/jphysiol.2012.241331

Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove.
Benjamin Dehay, Marta Martinez-Vicente, Alfredo Ramirez, Celine Perier, Christine Klein, Miquel Vila, Erwan Bezard
Autophagy. 2012-09-14
10.4161/auto.21011

A critique of available scales and presentation of the Non-Human Primate Dyskinesia Rating Scale.
Susan H. Fox, Tom H. Johnston, Qin Li, Jonathan Brotchie, Erwan Bezard
Mov. Disord.. 2012-09-13
10.1002/mds.25133

Animal models of Parkinson's disease: limits and relevance to neuroprotection studies.
Erwan Bezard, Zhenyu Yue, Deniz Kirik, Maria Grazia Spillantini
Mov Disord. 2012-07-02
10.1002/mds.25108

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.
B. Dehay, A. Ramirez, M. Martinez-Vicente, C. Perier, M.-H. Canron, E. Doudnikoff, A. Vital, M. Vila, C. Klein, E. Bezard
Proceedings of the National Academy of Sciences. 2012-05-30
10.1073/pnas.1112368109

Localization of endogenous morphine-like compounds in the mouse spinal cord.
Alexis Laux, François Delalande, Jinane Mouheiche, Denise Stuber, Alain Van Dorsselaer, Enrica Bianchi, Erwan Bezard, Pierrick Poisbeau, Yannick Goumon
J. Comp. Neurol.. 2012-03-06
10.1002/cne.22811

Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.
Benjamin Dehay, Deniz Dalkara, Sandra Dovero, Qin Li, Erwan Bezard
Sci Rep. 2012-02-09
10.1038/srep00253

Toward an animal model of restless legs syndrome?
Imad Ghorayeb, Erwan Bezard
Mov. Disord.. 2012-01-30
10.1002/mds.24905

Functional connectivity in human and monkey brain: new insights for understanding movement disorders?
Palma Pró-Sistiaga, Erwan Bézard
Mov. Disord.. 2012-01-01
10.1002/mds.24063

Modeling Parkinson's disease in primates: The MPTP model.
G. Porras, Q. Li, E. Bezard
Cold Spring Harbor Perspectives in Medicine. 2011-12-22
10.1101/cshperspect.a009308

Contribution of pre-synaptic mechanisms to L-DOPA-induced dyskinesia.
M. Carta, E. Bezard
Neuroscience. 2011-12-01
10.1016/j.neuroscience.2011.07.070

What should be said to the lay public regarding ADHD etiology.
Francois Gonon, Erwan Bezard, Thomas Boraud
Am. J. Med. Genet.. 2011-08-31
10.1002/ajmg.b.31236

Endogenous morphine-like compound immunoreactivity increases in parkinsonism.
G. Charron, E. Doudnikoff, A. Laux, A. Berthet, G. Porras, M.-H. Canron, P. Barroso-Chinea, Q. Li, C. Qin, M. Nosten-Bertrand, B. Giros, F. Delalande, A. Van Dorsselaer, A. Vital, Y. Goumon, E. Bezard
Brain. 2011-07-08
10.1093/brain/awr166

A new cerebral hemorrhage model in cynomolgus macaques created by injection of autologous anticoagulated blood into the brain.
Hua Zhu, Qin Li, Ming Feng, Yun-Xin Chen, Hao Li, Jin-Jiang Sun, Chun-Hua Zhao, Ren-Zhi Wang, Erwan Bezard, Chuan Qin
Journal of Clinical Neuroscience. 2011-07-01
10.1016/j.jocn.2010.11.038

A tale on animal models of Parkinson's disease.
Erwan Bezard, Serge Przedborski
Mov. Disord.. 2011-05-01
10.1002/mds.23696

Priorities in Parkinson's disease research.
Wassilios G. Meissner, Mark Frasier, Thomas Gasser, Christopher G. Goetz, Andres Lozano, Paola Piccini, José A. Obeso, Olivier Rascol, Anthony Schapira, Valerie Voon, David M. Weiner, François Tison, Erwan Bezard
Nat Rev Drug Discov. 2011-05-01
10.1038/nrd3430

New animal models of Parkinson's disease.
Benjamin Dehay, Erwan Bezard
Mov. Disord.. 2011-04-05
10.1002/mds.23546

New animal models of Parkinson's disease.
Benjamin Dehay, Erwan Bezard
Mov. Disord.. 2011-04-05
10.1002/mds.23546

Misrepresentation of neuroscience data might give rise to misleading conclusions in the media: the case of attention deficit hyperactivity disorder.
Francois Gonon, Erwan Bezard, Thomas Boraud
PLoS ONE. 2011-01-31
10.1371/journal.pone.0014618

Double-dissociation of the catecholaminergic modulation of synaptic transmission in the oval bed nucleus of the stria terminalis.
Michal Krawczyk, François Georges, Robyn Sharma, Xenos Mason, Amandine Berthet, Erwan Bézard, Éric C. Dumont
Journal of Neurophysiology. 2011-01-01
10.1152/jn.00710.2010

Migration and differentiation of human mesenchymal stem cells in the normal rat brain.
Jia-Mei Li, Hua Zhu, Shan Lu, Ying Liu, Qin Li, Paula Ravenscroft, Yan-Feng Xu, Lan Huang, Chun-Mei Ma, Erwan Bezard, Robert Chun-Hua Zhao, Ren-zhi Wang, Chuan Qin
Neurological Research. 2011-01-01
10.1179/016164110x12670144737819

Protein aggregation in the aging retina.
François Leger, Pierre-Olivier Fernagut, Marie-Hélène Canron, Sandy Léoni, Claude Vital, François Tison, Erwan Bezard, Anne Vital
J Neuropathol Exp Neurol. 2011-01-01
10.1097/nen.0b013e31820376cc

Molecular mechanisms of l-DOPA-induced dyskinesia.
Gilberto Fisone, Erwan Bezard
International Review of Neurobiology. 2011-01-01
10.1016/b978-0-12-381328-2.00004-3

Metabolic activity of the subthalamic nucleus in a primate model of L-dopa-unresponsive parkinsonism.
Pierre-Olivier Fernagut, Quentin Barraud, Erwan Bezard, Imad Ghorayeb, Francois Tison
Neurological Research. 2010-12-01
10.1179/016164110x12807570509934

Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia.
S. Fasano, E. Bezard, A. D'Antoni, V. Francardo, M. Indrigo, L. Qin, S. Dovero, M. Cerovic, M. A. Cenci, R. Brambilla
Proceedings of the National Academy of Sciences. 2010-11-29
10.1073/pnas.1012071107

Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys.
Pierre-Olivier Fernagut, Qin Li, Sandra Dovero, Piu Chan, Tao Wu, Paula Ravenscroft, Michael Hill, Zhenwen Chen, Erwan Bezard
PLoS ONE. 2010-11-22
10.1371/journal.pone.0014053

Neuroanatomical study of the A11 diencephalospinal pathway in the non-human primate.
Quentin Barraud, Ibrahim Obeid, Incarnation Aubert, Gregory Barrière, Hugues Contamin, Steve McGuire, Paula Ravenscroft, Gregory Porras, François Tison, Erwan Bezard, Imad Ghorayeb
PLoS ONE. 2010-10-13
10.1371/journal.pone.0013306

[GRK6, a new therapeutic approach to alleviate L-dopa-induced dyskinesia].
Amandine Berthet, Erwan Bézard
Med Sci (Paris). 2010-10-01
10.1051/medsci/20102610800

Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia.
Daniella Rylander, Martin Parent, Sean S. O'Sullivan, Sandra Dovero, Andrew J. Lees, Erwan Bezard, Laurent Descarries, M. Angela Cenci
Ann Neurol.. 2010-09-29
10.1002/ana.22097

A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.
Daniella Rylander, Hanna Iderberg, Qin Li, Andrzej Dekundy, Jinlan Zhang, Hao Li, Ren Baishen, Wojciech Danysz, Erwan Bezard, M. Angela Cenci
Neurobiology of Disease. 2010-09-01
10.1016/j.nbd.2010.05.001

Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia.
Emanuela Santini, Veronique Sgambato-Faure, Qin Li, Marc Savasta, Sandra Dovero, Gilberto Fisone, Erwan Bezard
PLoS ONE. 2010-08-23
10.1371/journal.pone.0012322

Genes regulated in MPTP-treated macaques and human Parkinson's disease suggest a common signature in prefrontal cortex.
Markus Storvik, Marie-Jeanne Arguel, Sandra Schmieder, Audrey Delerue-Audegond, Qin Li, Chuan Qin, Anne Vital, Bernard Bioulac, Christian E. Gross, Garry Wong, Jean-Louis Nahon, Erwan Bezard
Neurobiology of Disease. 2010-06-01
10.1016/j.nbd.2010.02.008

Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease.
M. R. Ahmed, A. Berthet, E. Bychkov, G. Porras, Q. Li, B. H. Bioulac, Y. T. Carl, B. Bloch, S. Kook, I. Aubert, S. Dovero, E. Doudnikoff, V. V. Gurevich, E. V. Gurevich, E. Bezard
Science Translational Medicine. 2010-04-21
10.1126/scitranslmed.3000664

Synaptic recruitment of AMPA glutamate receptor subunits in levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate.
Monty A. Silverdale, Christopher Kobylecki, Penelope J. Hallett, Qin Li, Anthone W. Dunah, Paula Ravenscroft, Erwan Bezard, Jonathan M. Brotchie
Synapse. 2010-02-01
10.1002/syn.20739

Treating Parkinson's disease: preserve the spines! (Commentary on Soderstrom et al.).
Erwan Bezard
European Journal of Neuroscience. 2010-02-01
10.1111/j.1460-9568.2010.07117.x

Basal Ganglia circuits underlying the pathophysiology of levodopa-induced dyskinesia.
Pedro Barroso-Chinea
Front. Neuroanat.. 2010-01-01
10.3389/fnana.2010.00131

Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders.
Valerie Voon, Pierre-Olivier Fernagut, Jeff Wickens, Christelle Baunez, Manuel Rodriguez, Nancy Pavon, Jorge L Juncos, José A Obeso, Erwan Bezard
The Lancet Neurology. 2009-12-01
10.1016/s1474-4422(09)70287-x

Dopamine receptors and L-dopa-induced dyskinesia.
Amandine Berthet, Erwan Bezard
Parkinsonism & Related Disorders. 2009-12-01
10.1016/s1353-8020(09)70827-2

IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP.
Agnès Nadjar, Olivier Berton, Shuhong Guo, Patricia Leneuve, Sandra Dovero, Elsa Diguet, François Tison, Baolu Zhao, Martin Holzenberger, Erwan Bezard
Neurobiology of Aging. 2009-12-01
10.1016/j.neurobiolaging.2008.02.009

Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms.
Maria C Rodriguez-Oroz, Marjan Jahanshahi, Paul Krack, Irene Litvan, Raúl Macias, Erwan Bezard, José A Obeso
The Lancet Neurology. 2009-12-01
10.1016/s1474-4422(09)70293-5

Involvement of canonical and non-canonical D1 dopamine receptor signalling pathways in L-dopa-induced dyskinesia.
Céline Guigoni, Erwan Bezard
Parkinsonism & Related Disorders. 2009-12-01
10.1016/s1353-8020(09)70783-7

Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders.
Valerie Voon, Pierre-Olivier Fernagut, Jeff Wickens, Christelle Baunez, Manuel Rodriguez, Nancy Pavon, Jorge L Juncos, José A Obeso, Erwan Bezard
The Lancet Neurology. 2009-12-01
10.1016/s1474-4422(09)70287-x

Dopamine receptors and L-dopa-induced dyskinesia.
Amandine Berthet, Erwan Bezard
Parkinsonism & Related Disorders. 2009-12-01
10.1016/s1353-8020(09)70827-2

Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms.
Maria C Rodriguez-Oroz, Marjan Jahanshahi, Paul Krack, Irene Litvan, Raúl Macias, Erwan Bezard, José A Obeso
The Lancet Neurology. 2009-12-01
10.1016/s1474-4422(09)70293-5

Involvement of canonical and non-canonical D1 dopamine receptor signalling pathways in L-dopa-induced dyskinesia.
Céline Guigoni, Erwan Bezard
Parkinsonism & Related Disorders. 2009-12-01
10.1016/s1353-8020(09)70783-7

Sleep disorders in Parkinson's disease: the contribution of the MPTP non-human primate model.
Quentin Barraud, Virginie Lambrecq, Claude Forni, Steve McGuire, Michael Hill, Bernard Bioulac, Emmanuel Balzamo, Erwan Bezard, François Tison, Imad Ghorayeb
Experimental Neurology. 2009-10-01
10.1016/j.expneurol.2009.07.019

High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster.
René Reese, Giselle Charron, Agnès Nadjar, Incarnation Aubert, Marie-Laure Thiolat, Melanie Hamann, Angelika Richter, Erwan Bezard, Wassilios G Meissner
Neurobiology of Disease. 2009-09-01
10.1016/j.nbd.2009.05.022

Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease.
Olivier Berton, Céline Guigoni, Qin Li, Bernard H. Bioulac, Incarnation Aubert, Christian E. Gross, Ralph J. DiLeone, Eric J. Nestler, Erwan Bezard
Biological Psychiatry. 2009-09-01
10.1016/j.biopsych.2009.04.005

The nigrostriatal pathway in Creutzfeldt-Jakob disease.
Anne Vital, Pierre-Olivier Fernagut, Marie-Hélène Canron, Julien Joux, Erwan Bezard, Marie-Laure Martin-Negrier, Claude Vital, François Tison
J Neuropathol Exp Neurol. 2009-07-01
10.1097/nen.0b013e3181abdae8

Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia.
A. Berthet, G. Porras, E. Doudnikoff, H. Stark, M. Cador, E. Bezard, B. Bloch
Journal of Neuroscience. 2009-04-15
10.1523/jneurosci.5884-08.2009

The pathologic features of neurocutaneous melanosis in a cynomolgus macaque.
Y. Chen, W. Deng, H. Zhu, J. Li, Y. Xu, X. Dai, C. Jia, Q. Kong, L. Huang, Y. Liu, C. Ma, C. Xiao, Q. Li, E. Bezard, C. Qin
Vet Pathol. 2009-03-09
10.1354/vp.08-vp-0243-q-bc

Antagonizing L-type Ca2+ channel reduces development of abnormal involuntary movement in the rat model of L-3,4-dihydroxyphenylalanine-induced dyskinesia.
Stefan Schuster, Evelyne Doudnikoff, Daniella Rylander, Amandine Berthet, Incarnation Aubert, Carina Ittrich, Bertrand Bloch, M. Angela Cenci, D. James Surmeier, Bastian Hengerer, Erwan Bezard
Biological Psychiatry. 2009-03-01
10.1016/j.biopsych.2008.09.008

Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism.
t. chaumette, t. lebouvier, p. aubert, b. lardeux, c. qin, q. li, d. accary, e. bézard, s. bruley des varannes, p. derkinderen, m. neunlist
Neurogastroenterology & Motility. 2009-02-01
10.1111/j.1365-2982.2008.01226.x

Priming for l-dopa-induced dyskinesia in Parkinson's disease: a feature inherent to the treatment or the disease?
Agnès Nadjar, Charles R. Gerfen, Erwan Bezard
Progress in Neurobiology. 2009-01-01
10.1016/j.pneurobio.2008.09.013

The vascular endothelial cell is a new origin of melanin pigment on cynomolgus macaque with neurocutaneous melanosis.
Chuan Qin, Hua Zhu, Yunxin Chen, Jiamei Li, Wei Deng, Yanfeng Xu, Xiaowei Dai, Chunshi Jia, Qi Kong, Lan Huang, Yali Liu, Chunmei Ma, Chong Xiao, Ying Liu, Qin Li, Erwan Bezard
Pigment Cell & Melanoma Research. 2008-12-01
10.1111/j.1755-148x.2008.00507.x

Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia.
A. Munoz, Q. Li, F. Gardoni, E. Marcello, C. Qin, T. Carlsson, D. Kirik, M. Di Luca, A. Bjorklund, E. Bezard, M. Carta
Brain. 2008-10-24
10.1093/brain/awn235

Striatal histone modifications in models of levodopa-induced dyskinesia.
Anthony P. Nicholas, Farah D. Lubin, Penelope J. Hallett, Padmapriya Vattem, Paula Ravenscroft, Erwan Bezard, Shaobo Zhou, Susan H. Fox, Jonathan M. Brotchie, J. David Sweatt, David G. Standaert
J Neurochem. 2008-07-01
10.1111/j.1471-4159.2008.05417.x

Differential behavioral effects of partial bilateral lesions of ventral tegmental area or substantia nigra pars compacta in rats.
E.Y. Pioli, W. Meissner, R. Sohr, C.E. Gross, E. Bezard, B.H. Bioulac
Neuroscience. 2008-06-01
10.1016/j.neuroscience.2008.01.084

Intratelencephalic corticostriatal neurons equally excite striatonigral and striatopallidal neurons and their discharge activity is selectively reduced in experimental parkinsonism.
Bérangère Ballion, Nicolas Mallet, Erwan Bézard, José Luis Lanciego, Francois Gonon
European Journal of Neuroscience. 2008-04-25
10.1111/j.1460-9568.2008.06192.x

The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor lovastatin reduces severity of L-DOPA-induced abnormal involuntary movements in experimental Parkinson's disease.
S. Schuster, A. Nadjar, J. T. Guo, Q. Li, C. Ittrich, B. Hengerer, E. Bezard
Journal of Neuroscience. 2008-04-23
10.1523/jneurosci.4720-07.2008

[Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure].
Erwan Bezard
Med Sci (Paris). 2008-04-01
10.1051/medsci/2008244368

Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure.
Birger Scholz, Marcus Svensson, Henrik Alm, Karl Sköld, Maria Fälth, Kim Kultima, Céline Guigoni, Evelyne Doudnikoff, Qin Li, Alan R. Crossman, Erwan Bezard, Per E. Andrén
PLoS ONE. 2008-02-13
10.1371/journal.pone.0001589

Neuroprotective effects of rotigotine in the acute MPTP-lesioned mouse model of Parkinson's disease.
Dieter Scheller, Christine Stichel-Gunkel, Hermann Lübbert, Gregory Porras, Paula Ravenscroft, Michael Hill, Erwan Bezard
Neuroscience Letters. 2008-02-01
10.1016/j.neulet.2007.12.001

Preclinical development of gene therapy for Parkinson's disease.
Grégory Porras, Erwan Bezard
Experimental Neurology. 2008-01-01
10.1016/j.expneurol.2007.08.003

RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease.
S. J. Gold, C. V. Hoang, B. W. Potts, G. Porras, E. Pioli, K. W. Kim, A. Nadjar, C. Qin, G. J. LaHoste, Q. Li, B. H. Bioulac, J. L. Waugh, E. Gurevich, R. L. Neve, E. Bezard
Journal of Neuroscience. 2007-12-26
10.1523/jneurosci.4223-07.2007

Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway.
Shuhong Guo, Jingqi Yan, Tangbin Yang, Xianqiang Yang, Erwan Bezard, Baolu Zhao
Biological Psychiatry. 2007-12-01
10.1016/j.biopsych.2007.04.020

Noradrenergic modulation of subthalamic nucleus activity: behavioral and electrophysiological evidence in intact and 6-hydroxydopamine-lesioned rats.
P. Belujon, E. Bezard, A. Taupignon, B. Bioulac, A. Benazzouz
Journal of Neuroscience. 2007-09-05
10.1523/jneurosci.2583-07.2007

Altered D(1) dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates.
Céline Guigoni, Evelyne Doudnikoff, Qin Li, Bertrand Bloch, Erwan Bezard
Neurobiology of Disease. 2007-05-01
10.1016/j.nbd.2007.02.001

Impact of chronic subthalamic high-frequency stimulation on metabolic basal ganglia activity: a 2-deoxyglucose uptake and cytochrome oxidase mRNA study in a macaque model of Parkinson's disease.
Wassilios Meissner, Celine Guigoni, Laetitia Cirilli, Maurice Garret, Bernard H. Bioulac, Christian E. Gross, Erwan Bezard, Abdelhamid Benazzouz
European Journal of Neuroscience. 2007-04-05
10.1111/j.1460-9568.2007.05406.x

Enhanced preproenkephalin-B-derived opioid transmission in striatum and subthalamic nucleus converges upon globus pallidus internalis in L-3,4-dihydroxyphenylalanine-induced dyskinesia.
Incarnation Aubert, Céline Guigoni, Qin Li, Sandra Dovero, Bernard H. Bioulac, Christian E. Gross, Alan R. Crossman, Bertrand Bloch, Erwan Bezard
Biological Psychiatry. 2007-04-01
10.1016/j.biopsych.2006.06.038

Rotigotine treatment partially protects from MPTP toxicity in a progressive macaque model of Parkinson's disease.
Dieter Scheller, Piu Chan, Qin Li, Tao Wu, Renling Zhang, Le Guan, Paula Ravenscroft, Celine Guigoni, Alan R. Crossman, Michael Hill, Erwan Bezard
Experimental Neurology. 2007-02-01
10.1016/j.expneurol.2006.08.026

Shaping of motor responses by incentive values through the basal ganglia.
B. Pasquereau, A. Nadjar, D. Arkadir, E. Bezard, M. Goillandeau, B. Bioulac, C. E. Gross, T. Boraud
Journal of Neuroscience. 2007-01-31
10.1523/jneurosci.3745-06.2007

Novel pharmacological targets for the treatment of Parkinson's disease.
Anthony H. V. Schapira, Erwan Bezard, Jonathan Brotchie, Frédéric Calon, Graham L. Collingridge, Borris Ferger, Bastian Hengerer, Etienne Hirsch, Peter Jenner, Nicolas Le Novère, José A. Obeso, Michael A. Schwarzschild, Umberto Spampinato, Giora Davidai
Nat Rev Drug Discov. 2006-10-01
10.1038/nrd2087

A call for clinically driven experimental design in assessing neuroprotection in experimental Parkinsonism.
Erwan Bezard
Behavioural Pharmacology. 2006-09-01
10.1097/00008877-200609000-00003

Traditional Chinese medicine for Parkinson's disease: a review of Chinese literature.
Qin Li, Deming Zhao, Erwan Bezard
Behavioural Pharmacology. 2006-09-01
10.1097/00008877-200609000-00006

Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia.
Nadjar A, Brotchie JM, Guigoni C, Li Q, Zhou SB, Wang GJ, Ravenscroft P, Georges F, Crossman AR, Bezard E.
Journal of Neuroscience. 2006-08-23
10.1523/jneurosci.2582-06.2006

Temporal and spatial alterations in GPi neuronal encoding might contribute to slow down movement in Parkinsonian monkeys.
Arthur Leblois, Wassilios Meissner, Erwan Bezard, Bernard Bioulac, Christian E. Gross, Thomas Boraud
European Journal of Neuroscience. 2006-08-01
10.1111/j.1460-9568.2006.04984.x

5-HT1A receptor agonist-mediated protection from MPTP toxicity in mouse and macaque models of Parkinson's disease.
Erwan Bezard, Irene Gerlach, Rosario Moratalla, Christian E. Gross, Reinhard Jork
Neurobiology of Disease. 2006-07-01
10.1016/j.nbd.2006.02.003

Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine.
Wassilios Meissner, Paula Ravenscroft, René Reese, Daniel Harnack, Rudolf Morgenstern, Andreas Kupsch, Henrik Klitgaard, Bernard Bioulac, Christian E. Gross, Erwan Bezard, Thomas Boraud
Neurobiology of Disease. 2006-06-01
10.1016/j.nbd.2006.01.009

Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice.
Ainhoa Bilbao, Andrea Cippitelli, Ana Belén Martín, Noelia Granado, Oscar Ortiz, Erwan Bezard, Jiang-Fan Chen, Miguel Navarro, Fernando Rodríguez de Fonseca, R Moratalla
Psychopharmacology. 2006-02-10
10.1007/s00213-005-0284-0

The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders.
L. Leriche, E. Bezard, C. Gross, O. Guillin, B. Foll, J. Diaz, P. Sokoloff
CNSNDDT. 2006-02-01
10.2174/187152706784111551

The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders.
L. Leriche, E. Bezard, C. Gross, O. Guillin, B. Foll, J. Diaz, P. Sokoloff
CNSNDDT. 2006-02-01
10.2174/187152706784111551

Normalization and expression changes in predefined sets of proteins using 2D gel electrophoresis: a proteomic study of L-DOPA induced dyskinesia in an animal model of Parkinson's disease using DIGE.
Kim Kultima, Birger Scholz, Henrik Alm, Karl Skold, Marcus Svensson, Alan R Crossman, Erwan Bezard, Per E Andren, Ingrid Lonnstedt
BMC Bioinformatics. 2006-01-01
10.1186/1471-2105-7-475

Unraveling substantia nigra sequential gene expression in a progressive MPTP-lesioned macaque model of Parkinson's disease.
F BASSILANA, N MACE, Q LI, J STUTZMANN, C GROSS, L PRADIER, J BENAVIDES, J MENAGER, E BEZARD
Neurobiology of Disease. 2005-10-01
10.1016/j.nbd.2005.02.005

[Animal models of parkinsonism]
I. Ghorayeb, E. Bezard, P.O. Fernagut, B. Bioulac, F. Tison
Revue Neurologique. 2005-10-01
10.1016/s0035-3787(05)85154-9

Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway.
Shuhong Guo, Erwan Bezard, Baolu Zhao
Free Radical Biology and Medicine. 2005-09-01
10.1016/j.freeradbiomed.2005.04.022

Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway.
Shuhong Guo, Erwan Bezard, Baolu Zhao
Free Radical Biology and Medicine. 2005-09-01
10.1016/j.freeradbiomed.2005.04.022

Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning.
Céline Guigoni, Sandra Dovero, Incarnation Aubert, Qin Li, Bernard H. Bioulac, Bertrand Bloch, Eugenia V. Gurevich, Christian E. Gross, Erwan Bezard
European Journal of Neuroscience. 2005-07-01
10.1111/j.1460-9568.2005.04196.x

Investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria.
Yu-Xiang Xie, Erwan Bezard, Bao-Lu Zhao
J. Biol. Chem.. 2005-06-27
10.1074/jbc.m504664200

Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors.
C. Guigoni, I. Aubert, Q. Li, V.V. Gurevich, J.L. Benovic, S. Ferry, U. Mach, H. Stark, L. Leriche, K. Håkansson, Bernard H. Bioulac, Christian E. Gross, Pierre Sokoloff, Gilberto Fisone, E.V. Gurevich, Bertrand Bloch, Erwan Bezard
Parkinsonism & Related Disorders. 2005-06-01
10.1016/j.parkreldis.2004.11.005

Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
P.J. Hallett, A.W. Dunah, P. Ravenscroft, S. Zhou, E. Bezard, A.R. Crossman, J.M. Brotchie, D.G. Standaert
Neuropharmacology. 2005-03-01
10.1016/j.neuropharm.2004.11.008

L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain.
E. Bezard, C.E. Gross, Li Qin, V.V. Gurevich, J.L. Benovic, E.V. Gurevich
Neurobiology of Disease. 2005-03-01
10.1016/j.nbd.2004.10.005

Partial bilateral mesencephalic lesions affect D1 but not D2 binding in both the striatum and cortex.
Elsa Pioli, Reinhard Sohr, Wassilios Meissner, Nicole Barthe, Christian E. Gross, Erwan Bezard, Bernard H. Bioulac
Neurochemistry International. 2004-12-01
10.1016/j.neuint.2004.06.003

Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia.
Incarnation Aubert, Céline Guigoni, Kerstin Håkansson, Qin Li, Sandra Dovero, Nicole Barthe, Bernard H. Bioulac, Christian E. Gross, Gilberto Fisone, Bertrand Bloch, Erwan Bezard
Ann Neurol.. 2004-10-27
10.1002/ana.20296

Asymmetrically lesioned mesencephalon in healthy rodents: call for caution.
Elsa Y. Pioli, Sandra Dovero, Bernard H. Bioulac, Christian E. Gross, Erwan Bezard
Brain Research. 2004-10-01
10.1016/j.brainres.2004.07.014

Rise and fall of minocycline in neuroprotection: need to promote publication of negative results.
Elsa Diguet, Christian E. Gross, François Tison, Erwan Bezard
Experimental Neurology. 2004-09-01
10.1016/j.expneurol.2004.05.016

Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys.
A. Hsu
Journal of Pharmacology and Experimental Therapeutics. 2004-08-05
10.1124/jpet.104.071142

Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease.
Elsa Diguet, Pierre-Olivier Fernagut, Xing Wei, Yansheng Du, Richard Rouland, Christian Gross, Erwan Bezard, François Tison
European Journal of Neuroscience. 2004-06-01
10.1111/j.0953-816x.2004.03372.x

Neuroprotective strategies for Parkinson's disease: conceptual limits of animal models and clinical trials.
Wassilios Meissner, Michael P. Hill, François Tison, Christian E. Gross, Erwan Bezard
Trends in Pharmacological Sciences. 2004-05-01
10.1016/j.tips.2004.03.003

Levetiracetam potentiates the antidyskinetic action of amantadine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primate model of Parkinson's disease.
M. P. Hill
Journal of Pharmacology and Experimental Therapeutics. 2004-04-02
10.1124/jpet.104.066191

High-frequency stimulation of both zona incerta and subthalamic nucleus induces a similar normalization of basal ganglia metabolic activity in experimental parkinsonism.
ABDELHAMID BENAZZOUZ, CHUN HWEI TAI, WASSILIOS MEISSNER, BERNARD BIOULAC, ERWAN BEZARD, CHRISTIAN GROSS
The FASEB Journal. 2004-03-01
10.1096/fj.03-0576fje

High frequency stimulation of the entopeduncular nucleus has no effect on striatal dopaminergic transmission.
Wassilios Meissner, Daniel Harnack, Nora Hoessle, Erwan Bezard, Christine Winter, Rudolf Morgenstern, Andreas Kupsch
Neurochemistry International. 2004-03-01
10.1016/s0197-0186(03)00138-4

Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque.
Erwan Bezard, Michael P. Hill, Alan R. Crossman, Jonathan M. Brotchie, Anne Michel, Renee Grimée, Henrik Klitgaard
European Journal of Pharmacology. 2004-02-01
10.1016/j.ejphar.2003.11.065

Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque.
Erwan Bezard, Michael P. Hill, Alan R. Crossman, Jonathan M. Brotchie, Anne Michel, Renee Grimée, Henrik Klitgaard
European Journal of Pharmacology. 2004-02-01
10.1016/j.ejphar.2003.11.065

Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment.
E. Diguet, C. E. Gross, E. Bezard, F. Tison, N. Stefanova, G. K. Wenning, B. Ravina, S. Fagan, R. Hart, C. Hovinga, D. Murphy, T. Dawson, J. Marler
Neurology. 2004-01-12
10.1212/wnl.62.1.158

Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment.
E. Diguet, C. E. Gross, E. Bezard, F. Tison, N. Stefanova, G. K. Wenning, B. Ravina, S. Fagan, R. Hart, C. Hovinga, D. Murphy, T. Dawson, J. Marler
Neurology. 2004-01-12
10.1212/wnl.62.1.158

Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway.
Oliver Guillin, Nathalie Griffon, Jorge Diaz, Bernard Le Foll, Erwan Bezard, Christian Gross, Chris Lammers, Holger Stark, Patrick Carroll, Jean-Charles Schwartz
International Review of Neurobiology. 2004-01-01
10.1016/s0074-7742(04)59016-5

Levetiracetam Interferes With the L-dopa priming process in MPTP-lesioned drug-naive marmosets.
Michael P Hill, Jonathan M Brotchie, Alan R Crossman, Erwan Bezard, Anne Michel, Renee Grim??e, Henrik Klitgaard
Clinical Neuropharmacology. 2004-01-01
10.1097/01.wnf.0000135478.70905.3d

Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway.
Oliver Guillin, Nathalie Griffon, Jorge Diaz, Bernard Le Foll, Erwan Bezard, Christian Gross, Chris Lammers, Holger Stark, Patrick Carroll, Jean-Charles Schwartz
International Review of Neurobiology. 2004-01-01
10.1016/s0074-7742(04)59016-5

Levetiracetam Interferes With the L-dopa priming process in MPTP-lesioned drug-naive marmosets.
Michael P Hill, Jonathan M Brotchie, Alan R Crossman, Erwan Bezard, Anne Michel, Renee Grim??e, Henrik Klitgaard
Clinical Neuropharmacology. 2004-01-01
10.1097/01.wnf.0000135478.70905.3d

Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson's disease.
Olivier Guillin, Nathalie Griffon, Erwan Bezard, Ludovic Leriche, Jorge Diaz, Christian Gross, Pierre Sokoloff
European Journal of Pharmacology. 2003-11-01
10.1016/j.ejphar.2003.08.096

Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson's disease.
Olivier Guillin, Nathalie Griffon, Erwan Bezard, Ludovic Leriche, Jorge Diaz, Christian Gross, Pierre Sokoloff
European Journal of Pharmacology. 2003-11-01
10.1016/j.ejphar.2003.08.096

Electrophysiological and metabolic evidence that high-frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the substantia nigra reticulata.
CHUN-HWEI TAI, THOMAS BORAUD, ERWAN BEZARD, BERNARD BIOULAC, CHRISTIAN GROSS, ABDELHAMID BENAZZOUZ
The FASEB Journal. 2003-10-01
10.1096/fj.03-0163com

Novel antiepileptic drug levetiracetam decreases dyskinesia elicited by L-dopa and ropinirole in the MPTP-lesioned marmoset.
Michael P. Hill, Erwan Bezard, Steven G. McGuire, Alan R. Crossman, Jonathan M. Brotchie, Ann Michel, Renee Grimée, Henrik Klitgaard
Mov. Disord.. 2003-08-21
10.1002/mds.10542

Neuroprotection for Parkinson's disease: a call for clinically driven experimental design.
Erwan Bezard
The Lancet Neurology. 2003-07-01
10.1016/s1474-4422(03)00432-0

Presymptomatic diagnosis of experimental Parkinsonism with 123I-PE2I SPECT.
Caroline Prunier, Erwan Bézard, Jérôme Montharu, Marina Mantzarides, Jean-Claude Besnard, Jean-Louis Baulieu, Christian Gross, Denis Guilloteau, Sylvie Chalon
NeuroImage. 2003-07-01
10.1016/s1053-8119(03)00163-0

Neuroprotection for Parkinson's disease: a call for clinically driven experimental design.
Erwan Bezard
The Lancet Neurology. 2003-07-01
10.1016/s1474-4422(03)00432-0

Presymptomatic diagnosis of experimental Parkinsonism with 123I-PE2I SPECT.
Caroline Prunier, Erwan Bézard, Jérôme Montharu, Marina Mantzarides, Jean-Claude Besnard, Jean-Louis Baulieu, Christian Gross, Denis Guilloteau, Sylvie Chalon
NeuroImage. 2003-07-01
10.1016/s1053-8119(03)00163-0

Compensatory regulation of striatal neuropeptide gene expression occurs before changes in metabolic activity of basal ganglia nuclei.
Wassilios Meissner, Sandra Dovero, Bernard Bioulac, Christian E. Gross, Erwan Bezard
Neurobiology of Disease. 2003-06-01
10.1016/s0969-9961(03)00011-1

Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function.
Erwan Bézard, Sandrine Ferry, Ulrich Mach, Holger Stark, Ludovic Leriche, Thomas Boraud, Christian Gross, Pierre Sokoloff
Nat Med. 2003-05-12
10.1038/nm875

Presymptomatic compensation in Parkinson's disease is not dopamine-mediated.
Erwan Bezard, Christian E. Gross, Jonathan M. Brotchie
Trends in Neurosciences. 2003-04-01
10.1016/s0166-2236(03)00038-9

Presymptomatic compensation in Parkinson's disease is not dopamine-mediated.
Erwan Bezard, Christian E. Gross, Jonathan M. Brotchie
Trends in Neurosciences. 2003-04-01
10.1016/s0166-2236(03)00038-9

Pattern of levodopa-induced striatal changes is different in normal and MPTP-lesioned mice.
Christian E. Gross, Paula Ravenscroft, Sandra Dovero, Mohamed Jaber, Bernard Bioulac, Erwan Bezard
Journal of Neurochemistry. 2003-03-01
10.1046/j.1471-4159.2003.01600.x

The deafferented nonhuman primate is not a reliable model of intractable pain.
Elsa Y. Pioli, Christian E. Gross, Wassilios Meissner, Bernard H. Bioulac, Erwan Bezard
Neurological Research. 2003-03-01
10.1179/016164103101201274

Pattern of levodopa-induced striatal changes is different in normal and MPTP-lesioned mice.
Christian E. Gross, Paula Ravenscroft, Sandra Dovero, Mohamed Jaber, Bernard Bioulac, Erwan Bezard
Journal of Neurochemistry. 2003-03-01
10.1046/j.1471-4159.2003.01600.x

Time-course of nigrostriatal degeneration in a progressive MPTP-lesioned macaque model of Parkinson's disease.
Wassilios Meissner, Caroline Prunier, Denis Guilloteau, Sylvie Chalon, Christian E. Gross, Erwan Bezard
MN. 2003-01-01
10.1385/mn:28:3:209

From single extracellular unit recording in experimental and human Parkinsonism to the development of a functional concept of the role played by the basal ganglia in motor control.
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian E. Gross
Progress in Neurobiology. 2002-03-01
10.1016/s0301-0082(01)00033-8

From single extracellular unit recording in experimental and human Parkinsonism to the development of a functional concept of the role played by the basal ganglia in motor control.
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian E. Gross
Progress in Neurobiology. 2002-03-01
10.1016/s0301-0082(01)00033-8

Pathophysiology of levodopa-induced dyskinesia: potential for new therapies.
Erwan Bezard, Jonathan M. Brotchie, Christian E. Gross
Nat Rev Neurosci. 2001-08-01
10.1038/35086062

Upregulation of striatal preproenkephalin gene expression occurs before the appearance of parkinsonian signs in 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine monkeys.
Erwan Bezard, Paula Ravenscroft, Christian E. Gross, Alan R. Crossman, Jonathan M. Brotchie
Neurobiology of Disease. 2001-04-01
10.1006/nbdi.2000.0375

Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey.
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian E. Gross
Brain. 2001-03-01
10.1093/brain/124.3.546

Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey.
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian E. Gross
Brain. 2001-03-01
10.1093/brain/124.3.546

Pallidal border cells: an anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey.
E Bezard, T Boraud, S Chalon, J.M Brotchie, D Guilloteau, C.E Gross
Neuroscience. 2001-02-01
10.1016/s0306-4522(00)00546-7

Pallidal border cells: An anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey
E Bezard, T Boraud, S Chalon, J.M Brotchie, D Guilloteau, C.E Gross
Neuroscience. 2001-02-01
10.1016/S0306-4522(00)00546-7

Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice.
Erwan Bezard, Sra Dovero, Christelle Imbert, Thomas Boraud, Christian E. Gross
Synapse. 2000-12-01
10.1002/1098-2396(20001201)38:33.3.co;2-1

Adaptive changes in the nigrostriatal pathway in response to increased 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration in the mouse.
Erwan Bezard, Mohamed Jaber, François Gonon, Alain Boireau, Bertrand Bloch, Christian E. Gross
European Journal of Neuroscience. 2000-08-01
10.1046/j.1460-9568.2000.00180.x

Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration.
Imad Ghorayeb, Pierre O. Fernagut, Incarnation Aubert, Erwan Bezard, Werner Poewe, Gregor K. Wenning, François Tison
Mov. Disord.. 2000-05-01
10.1002/1531-8257(200005)15:33.0.co;2-c

Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the Macaque monkey.
Christelle Imbert, Erwan Bezard, Stéphane Guitraud, Thomas Boraud, Christian E Gross
Journal of Neuroscience Methods. 2000-03-01
10.1016/s0165-0270(99)00184-3

Effects of riluzole on the electrophysiological activity of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey.
Th Boraud, E Bezard, J.M Stutzmann, B Bioulac, C.E Gross
Neuroscience Letters. 2000-03-01
10.1016/s0304-3940(00)00780-1

Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the Macaque monkey.
Christelle Imbert, Erwan Bezard, Stéphane Guitraud, Thomas Boraud, Christian E Gross
Journal of Neuroscience Methods. 2000-03-01
10.1016/s0165-0270(99)00184-3

Effects of riluzole on the electrophysiological activity of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey.
Th Boraud, E Bezard, J.M Stutzmann, B Bioulac, C.E Gross
Neuroscience Letters. 2000-03-01
10.1016/s0304-3940(00)00780-1

From experimentation to the surgical treatment of Parkinson's disease: prelude or suite in basal ganglia research?
C Gross
Progress in Neurobiology. 1999-12-01
10.1016/s0301-0082(99)00015-5

From experimentation to the surgical treatment of Parkinson's disease: prelude or suite in basal ganglia research?
C Gross
Progress in Neurobiology. 1999-12-01
10.1016/s0301-0082(99)00015-5

Effect of the alpha 2 adrenoreceptor antagonist, idazoxan, on motor disabilities in MPTP-treated monkey.
Erwan Bezard, Christine Brefel, Francois Tison, Helene Peyro-SaintPaul, Philippe Ladure, Olivier Rascol, Christian E. Gross
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1999-10-01
10.1016/s0278-5846(99)00067-6

Effect of the alpha 2 adrenoreceptor antagonist, idazoxan, on motor disabilities in MPTP-treated monkey.
Erwan Bezard, Christine Brefel, Francois Tison, Helene Peyro-SaintPaul, Philippe Ladure, Olivier Rascol, Christian E. Gross
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1999-10-01
10.1016/s0278-5846(99)00067-6

Trichloroethylene and parkinsonism: a human and experimental observation.
Dominique Guehl, Erwan Bezard, Sandra Dovero, Thomas Boraud, Bernard Bioulac, Christian Gross
Eur J Neurol. 1999-09-01
10.1046/j.1468-1331.1999.650609.x

Cortical stimulation and epileptic seizure: a study of the potential risk in primates.
Erwan Bezard, Thomas Boraud, Jean-Paul Nguyen, Francisco Velasco, Yves Keravel, Christian Gross
Neurosurgery. 1999-08-01
10.1097/00006123-199908000-00030

Involvement of the subthalamic nucleus in glutamatergic compensatory mechanisms.
Erwan Bezard, Thomas Boraud, Bernard Bioulac, Christian E. Gross
European Journal of Neuroscience. 1999-06-01
10.1046/j.1460-9568.1999.00627.x

Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.
Erwan Bezard, Christian E. Gross, Marie-Christine Fournier, Sandra Dovero, Bertrand Bloch, Mohamed Jaber
Experimental Neurology. 1999-02-01
10.1006/exnr.1998.6995

Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model.
Erwan Bezard, Jean-Marie Stutzmann, Christelle Imbert, Thomas Boraud, Alain Boireau, Christian E. Gross
European Journal of Pharmacology. 1998-09-01
10.1016/s0014-2999(98)00537-8

Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model
Erwan Bezard, Jean-Marie Stutzmann, Christelle Imbert, Thomas Boraud, Alain Boireau, Christian E. Gross
European Journal of Pharmacology. 1998-09-01
10.1016/S0014-2999(98)00537-8

Compensatory mechanisms in experimental and human parkinsonism: towards a dynamic approach.
Erwan Bezard, Christian E Gross
Progress in Neurobiology. 1998-06-01
10.1016/s0301-0082(98)00006-9

Glutamatergic compensatory mechanisms in experimental parkinsonism.
Erwan Bezard, Bernard Bioulac, Christian E. Gross
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1998-05-01
10.1016/s0278-5846(98)00030-x

Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey.
Th Boraud, E Bezard, D Guehl, B Bioulac, Ch Gross
Brain Research. 1998-03-01
10.1016/s0006-8993(97)01563-1

Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Th Boraud, E Bezard, D Guehl, B Bioulac, Ch Gross
Brain Research. 1998-03-01
10.1016/S0006-8993(97)01563-1

Experimental models of Parkinson's disease: from the static to the dynamic.
Erwan Bezard, Christelle Imbert, Christian E. Gross
Reviews in the Neurosciences. 1998-01-01
10.1515/revneuro.1998.9.2.71

Effects of different schedules of MPTP administration on dopaminergic neurodegeneration in mice.
Erwan Bezard, Sandra Dovero, Bernard Bioulac, Christian Gross
Experimental Neurology. 1997-11-01
10.1006/exnr.1997.6648

Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental parkinsonism.
E Bezard, T Boraud, B Bioulac, C.E Gross
Neuroscience. 1997-09-01
10.1016/s0306-4522(97)00226-1

Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental parkinsonism.
E Bezard, T Boraud, B Bioulac, C.E Gross
Neuroscience. 1997-09-01
10.1016/s0306-4522(97)00226-1

Kinetics of nigral degeneration in a chronic model of MPTP-treated mice.
Erwan Bezard, Sandra Dovero, Bernard Bioulac, Christian E Gross
Neuroscience Letters. 1997-09-01
10.1016/s0304-3940(97)00663-0

Kinetics of nigral degeneration in a chronic model of MPTP-treated mice
Erwan Bezard, Sandra Dovero, Bernard Bioulac, Christian E Gross
Neuroscience Letters. 1997-09-01
10.1016/S0304-3940(97)00663-0

A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey.
Erwan Bezard, Christelle Imbert, Xavier Deloire, Bernard Bioulac, Christian E Gross
Brain Research. 1997-08-01
10.1016/s0006-8993(97)00531-3

Subthalamic stimulation elicits hemiballismus in normal monkey.
Corinne Beurrier, Erwan Bezard, Bernard Bioulac, Christian Gross
NeuroReport. 1997-05-01
10.1097/00001756-199705060-00014

Presymptomatic revelation of experimental parkinsonism.
Erwan Bezard, Thomas Boraud, Bernard Bioulac, Christian E. Gross
NeuroReport. 1997-01-01
10.1097/00001756-199701200-00012

High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey.
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian Gross
Neuroscience Letters. 1996-08-01
10.1016/s0304-3940(96)12943-8

High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian Gross
Neuroscience Letters. 1996-08-01
10.1016/S0304-3940(96)12943-8