Biases in α-synuclein immuno-quantitation: a core problem for basic and ancillary studies of Parkinson’s disease and multiple system atrophy
Florent Laferrière, Ludivine Sabatier, Stéphane Claverol, Francesca De Giorgi, François Ichas
Transl Neurodegener. 2024-03-25
10.1186/s40035-024-00408-x

Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
Francesca De Giorgi, Ænora Letourneur, Marianna Kashyrina, Federica Zinghirino, Sandra Dovero, Nathalie Dutheil, Leslie-Ann Largitte, Marie-Laure Arotçarena, Erwan Bezard, Marie-Hélène Canron, Wassilios Meissner, Francesco De Nuccio, Dario Domenico Lofrumento, Florent Laferrière, François Ichas
Preprint - Research Square. 2024-02-07
10.21203/rs.3.rs-3921168/v1

Oligodendrocytes Prune Axons Containing α-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?
Francesco De Nuccio, Marianna Kashyrina, Francesca Serinelli, Florent Laferrière, Dario Domenico Lofrumento, Francesca De Giorgi and François Ichas
biomolecules. 2023-02-01
10.3390/biom13020269

A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine Induces Potent Immune Responses and Therapeutic Efficacy in Mice
Sabine Schmidhuber, Sandra Scheiblhofer, Richard Weiss, Mihály Cserepes, József Tóvári, Gabriele Gadermaier, Erwan Bezard, Francesca De Giorgi, Francois Ichas, Dirk Strunk, Markus Mandler
Vaccines. 2022-08-30
10.3390/vaccines10091432

α-Synuclein Fibrils as Penrose Machines: A Chameleon in the Gear
Francesca De Giorgi, Vladimir N. Uversky, François Ichas
Biomolecules. 2022-03-24
10.3390/biom12040494

Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, François Ichas
Biomolecules. 2022-03-11
10.3390/biom12030436

Similar neuronal imprint and no cross-seeded fibrils in α-synuclein aggregates from MSA and Parkinson’s disease
Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas
npj Parkinsons Dis.. 2022-01-13
10.1038/s41531-021-00264-w

Similar neuronal imprint and absence of cross-seeded partner fibrils in α-synuclein aggregates from MSA and Parkinson’s disease brains
Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas
Preprint bioRxiv. 2021-06-22
10.1101/2021.06.22.449410

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy
Florent Laferrière, Xin He, Federica Zinghirino, Evelyne Doudnikoff, Emilie Faggiani, Wassilios G. Meissner, Erwan Bezard, Francesca De Giorgi, François Ichas
Cells. 2020-10-29
10.3390/cells9112371

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons
Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
Sci. Adv.. 2020-10-01
10.1126/sciadv.abc4364

Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction
Zhenwei Yu, Min Shi, Tessandra Stewart, Pierre-Olivier Fernagut, Yang Huang, Chen Tian, Benjamin Dehay, Anzari Atik, Dishun Yang, Francesca De Giorgi, François Ichas, Marie-Hélène Canron, Roberto Ceravolo, Daniela Frosini, Han-Joon Kim, Tao Feng, Wassilios G Meissner, Jing Zhang
Brain. 2020-05-18
10.1093/brain/awaa110

In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains.
Fabio Cavaliere, Loic Cerf, Benjamin Dehay, Paula Ramos-Gonzalez, Francesca De Giorgi, Mathieu Bourdenx, Alban Bessede, Jose A. Obeso, Carlos Matute, François Ichas, Erwan Bezard
Neurobiology of Disease. 2017-07-01
10.1016/j.nbd.2017.04.011

The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer
C Rey, B Faustin, I Mahouche, R Ruggieri, C Brulard, F Ichas, I Soubeyran, L Lartigue & F De Giorgi
Oncogene. 2015-05
10.1038/onc.2015.379

HIPK1 drives p53 activation to limit colorectal cancer cell growth
Christophe Rey, Isabelle Soubeyran, Isabelle Mahouche, Stephane Pedeboscq, Alban Bessede, François Ichas, Francesca De Giorgi, Lydia Lartigue
Cell Cycle. 2013-06-15
10.4161/cc.24927

High-Throughput Flow Cytometry Analysis of Apoptosis
Francesca de Giorgi, François Ichas
High-Throughput Screening Methods in Toxicity Testing. 2013-03-04
10.1002/9781118538203.ch6

Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines
Stéphane Pédeboscq, Denis Gravier, Françoise Casadebaig, Geneviève Hou, Arnaud Gissot, Christophe Rey, François Ichas, Francesca De Giorgi, Lydia Lartigue, Jean-Paul Pometan
Bioorganic & Medicinal Chemistry. 2012-11-01
10.1016/j.bmc.2012.09.034

High-Throughput Flow Cytometry for Predicting Drug-Induced Hepatotoxicity
Marion Zanese, Laura Suter, Adrian Roth, Francesca De Giorgi, Francois Ichas
Clinical Flow Cytometry - Emerging Applications. 2012-05-16
10.5772/38270

Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein Kinase inhibitors in vitro
Stéphane Pédeboscq, Christophe Rey, Muriel Petit, Catherine Harpey, Francesca De Giorgi, François Ichas, Lydia Lartigue
PLoS ONE. 2012-05-08
10.1371/journal.pone.0036811

The polyphenolic ellagitannin vescalagin acts as a preferential catalytic inhibitor of the α isoform of human DNA topoisomerase II
Céline Auzanneau, Danièle Montaudon, Rémi Jacquet, Stéphane Puyo, Laurent Pouységu, Denis Deffieux, Assia Elkaoukabi-Chaibi, Francesca De Giorgi, François Ichas, Stéphane Quideau, Philippe Pourquier
Mol Pharmacol. 2012-04-23
10.1124/mol.111.077537

Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function
Isabelle Soubeyran, Isabelle Mahouche, Aude Grigoletto, Thierry Leste-Lasserre, Guillaume Drutel, Christophe Rey, Stephane Pedeboscq, France Blanchard, Veronique Brouste, Jean-Christophe Sabourin, Yves Bécouarn, Josy Reiffers, François Ichas, Francesca De Giorgi
The American Journal of Pathology. 2011-05-01
10.1016/j.ajpath.2011.01.021

Synthesis and study of antiproliferative activity of novel thienopyrimidines on glioblastoma cells
Stéphane Pédeboscq, Denis Gravier, Françoise Casadebaig, Geneviève Hou, Arnaud Gissot, Francesca De Giorgi, François Ichas, Jean Cambar, Jean-Paul Pometan
European Journal of Medicinal Chemistry. 2010-06-01
10.1016/j.ejmech.2010.02.032

Recombinant differential anchorage probes that tower over the spatial dimension of intracellular signals for high content screening and analysis
Laura Schembri, Marion Zanese, Gaelle Depierre-Plinet, Muriel Petit, Assia Elkaoukabi-Chaibi, Loic Tauzin, Cristina Florean, Lydia Lartigue, Chantal Medina, Christophe Rey, Francis Belloc, Josy Reiffers, François Ichas, Francesca De Giorgi
Anal. Chem.. 2009-12-01
10.1021/ac9015227

Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis
Flora Tomasello, Angela Messina, Lydia Lartigue, Laura Schembri, Chantal Medina, Simona Reina, Didier Thoraval, Marc Crouzet, François Ichas, Vito De Pinto, Francesca De Giorgi
Cell Res. 2009-08-11
10.1038/cr.2009.98

An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis
L. Lartigue, C. Medina, L. Schembri, P. Chabert, M. Zanese, F. Tomasello, R. Dalibart, D. Thoraval, M. Crouzet, F. Ichas, F. De Giorgi
Journal of Cell Science. 2008-10-07
10.1242/jcs.029587

High content analysis of γ-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer's disease
Cristina Florean, Enrico Zampese, Marion Zanese, Lucia Brunello, François Ichas, Francesca De Giorgi, Paola Pizzo
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2008-08-01
10.1016/j.bbamcr.2008.03.012

Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway
M. Beneteau, M. Pizon, B. Chaigne-Delalande, S. Daburon, P. Moreau, F. De Giorgi, F. Ichas, A. Rebillard, M.-T. Dimanche-Boitrel, J.-L. Taupin, J.-F. Moreau, P. Legembre
Molecular Cancer Research. 2008-03-14
10.1158/1541-7786.mcr-07-0331

The HA tag is cleaved and loses immunoreactivity during apoptosis
Laura Schembri, Renee Dalibart, Flora Tomasello, Patrick Legembre, François Ichas, Francesca De Giorgi
Nat Methods. 2007-02-01
10.1038/nmeth0207-107

Label-free optical imaging of mitochondria in live cells
David Lasne, Gerhard A. Blab, Francesca De Giorgi, François Ichas, Brahim Lounis, Laurent Cognet
Opt. Express. 2007-01-01
10.1364/OE.15.014184

Amplification of Fas-Mediated Apoptosis in Type II Cells via Microdomain Recruitment
Patrick Legembre, Sophie Daburon, Patrick Moreau, François Ichas, Francesca de Giorgi, Jean-François Moreau, Jean-Luc Taupin
MCB. 2005-08-01
10.1128/mcb.25.15.6811-6820.2005

Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion
Naoual L Benali-Furet, Mounia Chami, Ludivine Houel, Francesca De Giorgi, Fabienne Vernejoul, David Lagorce, Louis Buscail, Ralf Bartenschlager, François Ichas, Rosario Rizzuto, Patrizia Paterlini-Bréchot
Oncogene. 2005-05-09
10.1038/sj.onc.1208673

The permeability transition pore signals apoptosis by directing Bax translocation and multimerization.
Francesca De Giorgi, Lydia Lartigue, Manuel K. A. Bauer, Alexis Schubert, Stefan Grimm, George T. Hanson, S. James Remington, Richard J. Youle, François Ichas
FASEB j.. 2002-02-25
10.1096/fj.01-0269fje

Electrical coupling and plasticity of the mitochondrial network
F. De Giorgi, L. Lartigue, F. Ichas
Cell Calcium. 2000-11-01
10.1054/ceca.2000.0177

Time-resolved storage and retrieval of Ca2+ signals by mitochondria depends on matrix Ca2+ hotspots
François Ichas, Francesca Giorgi, Michel Duvert, Carmen A. Mannella, Michael Marko, Raffaele Colonna, Paolo Bernardi
Biology of the Cell. 1999-06-01
10.1016/s0248-4900(99)80046-x