Fabien Wagner
Équipe : NeuroDTx: Neuromodulation and Digital Therapeutics 
Chef d'équipe  |  CR  |  CNRS
Parcours
Formé d’abord en tant qu’ingénieur puis en neurosciences, j’effectue des recherches à l’intersection entre les Neurosciences et la Neuroingénierie. J’étudie comment la dynamique des réseaux neuronaux devient altérée dans des troubles neurologiques ou après une lésion, et comment restaurer leur comportement naturel en utilisant des approches de neuromodulation. Pendant mon Ph.D. à l’université Brown, j’ai développé de nouveaux outils permettant d’enregistrer et de stimuler le cerveau simultanément, et j’ai étudié les dynamiques corticales qui ont lieu pendant la transition vers des crises épileptiques dans des modèles rongeurs et des patients. Pendant mon travail de postdoctorat à l’Ecole Polytechnique Fédérale de Lausanne (EPFL), j’ai innové des neuroprothèses permettant de restaurer la locomotion dans des modèles primates (Nature 2016, Nature Protocols 2018). J’ai ensuite mené une équipe importante de scientifiques, d’ingénieurs et de cliniciens afin d’effectuer la translation de ces technologies chez des patients atteints de lésions de la moelle épinière, dans le contexte d’un premier essai clinique chez l’humain (Nature 2018).
En tant que chef d’équipe à l’Institut des Maladies Neurodégénératives au sein du Neurocampus de Bordeaux, je souhaite maintenant étendre l’utilisation des neuroprothèses au-delà de leur application actuelle dans le domaine moteur, vers les troubles neurocognitifs tels que les déficits de mémoire et la démence.
Publications
                
                    High-accuracy electrode implantation in deep brain structures using multi-camera neuronavigation in non-human primates
                    
                        Ankur Gupta, Adrien Boissenin, Nikolaos Vardalakis, Mathieu Taillade, Hugues Orignac, Nathalie Biendon, Sandra Dovero, Tho-Hai Nguyen, Amirouche Sadoun, Fabien B Wagner
                        J. Neural Eng.. 
                        2025-10-14
                    
                    
10.1088/1741-2552/ae135b
                
            
                
                    In vivo submillimeter diffusion MRI dataset of 9 macaque brains curated for tractography
                    
                        Alex Valcourt Caron, Nadège Corbin, Adrien Boissenin, Ankur Gupta, Tho-Hai Nguyen, Serge Anandra, Sylvain Miraux, Maxime Descoteaux, Laurent Petit, Fabien B. Wagner
                        Sci Data. 
                        2025-07-11
                    
                    
10.1038/s41597-025-05350-9
                
            
                
                    Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept
                    
                        Nicolas Hankov, Miroslav Caban, Robin Demesmaeker, Margaux Roulet, Salif Komi, Michele Xiloyannis, Anne Gehrig, Camille Varescon, Martina Rebeka Spiess, Serena Maggioni, Chiara Basla, Gleb Koginov, Florian Haufe, Marina D’Ercole, Cathal Harte, Sergio D. Hernandez-Charpak, Aurelie Paley, Manon Tschopp, Natacha Herrmann, Nadine Intering, Edeny Baaklini, Francesco Acquati, Charlotte Jacquet, Anne Watrin, Jimmy Ravier, Frédéric Merlos, Grégoire Eberlé, Katrien Van den Keybus, Hendrik Lambert, Henri Lorach, Rik Buschman, Nicholas Buse, Timothy Denison, Dino De Bon, Jaime E. Duarte, Robert Riener, Auke Ijspeert, Fabien Wagner, Sebastian Tobler, Léonie Asboth, Joachim von Zitzewitz, Jocelyne Bloch, Grégoire Courtine
                        Sci. Robot.. 
                        2025-03-12
                    
                    
10.1126/scirobotics.adn5564
                
            
                
                    A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation
                    
                        Nikolaos Vardalakis, Amélie Aussel, Nicolas P. Rougier, Fabien B. Wagner
                        eLife. 
                        2023-02-14
                    
                    
10.7554/eLife.87356.3
                
            
                
                    Neuroprosthetics: from sensorimotor to cognitive disorders
                    
                        Ankur Gupta, Nikolaos Vardalakis, Fabien B. Wagner
                        Comm Biol. 
                        2023-01-06
                    
                    
10.1038/s42003-022-04390-w
                
            
                
                    The neurons that restore walking after paralysis.
                    
                        Claudia Kathe, Michael A. Skinnider, Thomas H. Hutson, Nicola Regazzi, Matthieu Gautier, Robin Demesmaeker, Salif Komi, Steven Ceto, Nicholas D. James, Newton Cho, Laetitia Baud, Katia Galan, Kaya J. E. Matson, Andreas Rowald, Kyungjin Kim, Ruijia Wang, Karen Minassian, John O. Prior, Leonie Asboth, Quentin Barraud, Stéphanie P. Lacour, Ariel J. Levine, Fabien Wagner, Jocelyne Bloch, Jordan W. Squair, Grégoire Courtine
                        Nature. 
                        2022-11-09
                    
                    
10.1038/s41586-022-05385-7
                
            
                
                    Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
                    
                        Andreas Rowald, Salif Komi, Robin Demesmaeker, Edeny Baaklini, Sergio Daniel Hernandez-Charpak, Edoardo Paoles, Hazael Montanaro, Antonino Cassara, Fabio Becce, Bryn Lloyd, Taylor Newton, Jimmy Ravier, Nawal Kinany, Marina D’Ercole, Aurélie Paley, Nicolas Hankov, Camille Varescon, Laura McCracken, Molywan Vat, Miroslav Caban, Anne Watrin, Charlotte Jacquet, Léa Bole-Feysot, Cathal Harte, Henri Lorach, Andrea Galvez, Manon Tschopp, Natacha Herrmann, Moïra Wacker, Lionel Geernaert, Isabelle Fodor, Valentin Radevich, Katrien Van Den Keybus, Grégoire Eberle, Etienne Pralong, Maxime Roulet, Jean-Baptiste Ledoux, Eleonora Fornari, Stefano Mandija, Loan Mattera, Roberto Martuzzi, Bruno Nazarian, Stefan Benkler, Simone Callegari, Nathan Greiner, Benjamin Fuhrer, Martijn Froeling, Nik Buse, Tim Denison, Rik Buschman, Christian Wende, Damien Ganty, Jurriaan Bakker, Vincent Delattre, Hendrik Lambert, Karen Minassian, Cornelis A. T. van den Berg, Anne Kavounoudias, Silvestro Micera, Dimitri Van De Ville, Quentin Barraud, Erkan Kurt, Niels Kuster, Esra Neufeld, Marco Capogrosso, Leonie Asboth, Fabien B. Wagner, Jocelyne Bloch, Grégoire Courtine
                        Nat Med. 
                        2022-02-07
                    
                    
10.1038/s41591-021-01663-5
                
            
                
                    Spinal Cord Stimulation to Enable Leg Motor Control and Walking in People with Spinal Cord Injury
                    
                        Ismael Seáñez, Marco Capogrosso, Karen Minassian, Fabien B. Wagner
                        Neurorehabilitation Technology. 
                        2022-01-01
                    
                    
10.1007/978-3-031-08995-4_18
                
            
                
                    MRI‐Compatible and Conformal Electrocorticography Grids for Translational Research
                    
                        Florian Fallegger, Giuseppe Schiavone, Elvira Pirondini, Fabien B. Wagner, Nicolas Vachicouras, Ludovic Serex, Gregory Zegarek, Adrien May, Paul Constanthin, Marie Palma, Mehrdad Khoshnevis, Dirk Van Roost, Blaise Yvert, Grégoire Courtine, Karl Schaller, Jocelyne Bloch, Stéphanie P. Lacour
                        Adv. Sci.. 
                        2021-03-08
                    
                    
10.1002/advs.202003761
                
            
                
                    Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
                    
                        J. W. Squair, M. Gautier, L. Mahe, J.E. Soriano, A Rowald, A. Bichat, N. Cho, M. A. Anderson, N. D. James, J. Gandar, A. V. Incognito, G. Schiavone, Z. K. Sarafis, A. Laskaratos, K. Bartholdi, R. Demesmaeker, S. Komi, C. Moerman, B. Vaseghi, B. Scott, R. Rosentreter, C. Kathe, J. Ravier, L. McCracken, X. Kang, N. Vachicouras, F. Fallegger, I. Jelescu, Y. Cheng, Q. Li, R. Buschman, N. Buse, T. Denison, S. Dukelow, R. Charbonneau, I. Rigby, S. K. Boyd, P.J. Millar, E. M. Moraud, M. Capogrosso, F. B. Wagner, Q. Barraud, E. Bezard, S. P. Lacour, J. Bloch, G. Courtine, A. A. Phillips
                        Nature. 
                        2021-01-27
                    
                    
10.1038/s41586-020-03180-w
                
            
                
                    Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury
                    
                        Emanuele Formento, Karen Minassian, Fabien Wagner, Jean Baptiste Mignardot, Camille G. Le Goff-Mignardot, Andreas Rowald, Jocelyne Bloch, Silvestro Micera, Marco Capogrosso, Gregoire Courtine
                        Nat Neurosci. 
                        2018-10-31
                    
                    
10.1038/s41593-018-0262-6
                
            
                
                    Targeted neurotechnology restores walking in humans with spinal cord injury
                    
                        Fabien B. Wagner, Jean-Baptiste Mignardot, Camille G. Le Goff-Mignardot, Robin Demesmaeker, Salif Komi, Marco Capogrosso, Andreas Rowald, Ismael Seáñez, Miroslav Caban, Elvira Pirondini, Molywan Vat, Laura A. McCracken, Roman Heimgartner, Isabelle Fodor, Anne Watrin, Perrine Seguin, Edoardo Paoles, Katrien Van Den Keybus, Grégoire Eberle, Brigitte Schurch, Etienne Pralong, Fabio Becce, John Prior, Nicholas Buse, Rik Buschman, Esra Neufeld, Niels Kuster, Stefano Carda, Joachim von Zitzewitz, Vincent Delattre, Tim Denison, Hendrik Lambert, Karen Minassian, Jocelyne Bloch, Grégoire Courtine
                        Nature. 
                        2018-10-31
                    
                    
10.1038/s41586-018-0649-2
                
            
                
                    Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics.
                    
                        Marco Capogrosso, Fabien B. Wagner, Jerome Gandar, Eduardo Martin Moraud, Nikolaus Wenger, Tomislav Milekovic, Polina Shkorbatova, Natalia Pavlova, Pavel Musienko, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
                        Nat Protoc. 
                        2018-09-01
                    
                    
10.1038/s41596-018-0030-9
                
            
                
                    Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model.
                    
                        Giuseppe Schiavone, Fabien Wagner, Florian Fallegger, Xiaoyang Kang, Nicolas Vachicouras, Beatrice Barra, Marco Capogrosso, Jocelyne Bloch, Gregoire Courtine, Stephanie P. Lacour
                        2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 
                        2018-07-01
                    
                    
10.1109/embc.2018.8512584
                
            
                
                    A brain-spine interface alleviating gait deficits after spinal cord injury in primates.
                    
                        Marco Capogrosso, Tomislav Milekovic, David Borton, Fabien Wagner, Eduardo Martin Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jerome Gandar, Quentin Barraud, David Xing, Elodie Rey, Simone Duis, Yang Jianzhong, Wai Kin D. Ko, Qin Li, Peter Detemple, Tim Denison, Silvestro Micera, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
                        Nature. 
                        2016-11
                    
                    
10.1038/nature20118
                
            
                
                    Erratum: Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications (Journal of Neural Engineering (2012) 9 (016001))
                    
                        
                        J. Neural Eng.. 
                        2016-05-06
                    
                    
10.1088/1741-2560/13/3/039501
                
            
                
                    Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures.
                    
                        Fabien B. Wagner, Emad N. Eskandar, G. Rees Cosgrove, Joseph R. Madsen, Andrew S. Blum, N. Stevenson Potter, Leigh R. Hochberg, Sydney S. Cash, Wilson Truccolo
                        NeuroImage. 
                        2015-11-01
                    
                    
10.1016/j.neuroimage.2015.08.019
                
            
                
                    Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury.
                    
                        Rubia van den Brand, Jean-Baptiste Mignardot, Joachim von Zitzewitz, Camille Le Goff, Nicolas Fumeaux, Fabien Wagner, Marco Capogrosso, Eduardo Martin Moraud, Silvestro Micera, Brigitte Schurch, Armin Curt, Stefano Carda, Jocelyne Bloch, Grégoire Courtine
                        Annals of Physical and Rehabilitation Medicine. 
                        2015-09-01
                    
                    
10.1016/j.rehab.2015.04.003
                
            
                
                    Optogenetically induced spatiotemporal gamma oscillations and neuronal spiking activity in primate motor cortex.
                    
                        Yao Lu, Wilson Truccolo, Fabien B. Wagner, Carlos E. Vargas-Irwin, Ilker Ozden, Jonas B. Zimmermann, Travis May, Naubahar S. Agha, Jing Wang, Arto V. Nurmikko
                        Journal of Neurophysiology. 
                        2015-06-01
                    
                    
10.1152/jn.00792.2014
                
            
                
                    Modified toolbox for optogenetics in the nonhuman primate.
                    
                        Ji Dai, Ilker Ozden, Daniel I. Brooks, Fabien Wagner, Travis May, Naubahar S. Agha, Benjamin Brush, David Borton, Arto V. Nurmikko, David L. Sheinberg
                        Neurophoton. 
                        2015-05-29
                    
                    
10.1117/1.NPh.2.3.031202
                
            
                
                    Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy.
                    
                        Fabien B. Wagner, Wilson Truccolo, Jing Wang, Arto V. Nurmikko
                        Journal of Neurophysiology. 
                        2015-04-01
                    
                    
10.1152/jn.01040.2014
                
            
                
                    Detection of optogenetic stimulation in somatosensory cortex by non-human primates--towards artificial tactile sensation.
                    
                        Travis May, Ilker Ozden, Benjamin Brush, David Borton, Fabien Wagner, Naubahar Agha, David L. Sheinberg, Arto V. Nurmikko
                        PLoS ONE. 
                        2014-12-26
                    
                    
10.1371/journal.pone.0114529
                
            
                
                    Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications.
                    
                        Jing Wang, Fabien Wagner, David A Borton, Jiayi Zhang, Ilker Ozden, Rebecca D Burwell, Arto V Nurmikko, Rick van Wagenen, Ilka Diester, Karl Deisseroth
                        J. Neural Eng.. 
                        2011-12-07
                    
                    
10.1088/1741-2560/9/1/016001
                
            
                
                    Approaches to optical neuromodulation from rodents to non-human primates by integrated optoelectronic devices.
                    
                        Jing Wang, I. Ozden, M. Diagne, F. Wagner, D. Borton, B. Brush, N. Agha, R. Burwell, D. Sheinberg, I. Diester, K. Deisseroth, A. Nurmikko
                        2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 
                        2011-08-01
                    
                    
10.1109/iembs.2011.6091855