Purinergic mediated neuroinflammation and brain disorders

Neurological disorders rely on alterations of the central or peripheral nervous system that are caused by impairments of neuronal transmission or more global perturbations of local circuits that implicate glial cells. The scientific goal of our team is to understand the contribution of neuronal versus inflammatory signaling in brain disorders including amyotrophic lateral sclerosis (ALS), attention deficit/hyperactivity disorders (ADHD), chronic pain, and anxiety-related disorders. Our objectives are to determine (i) the contribution of purinergic signaling as a dual system, and (ii) the modulatory function of peptidergic signaling, both capable to regulate neuronal synaptic activation and microglial neuro-inflammatory reaction as well as developmental processes. We combine cellular, anatomical, functional and behavioral approaches from in vitro to animal models. We expect to reveal the respective contribution of neuronal versus inflammation signaling in several central disorders and to provide attractive novel strategies and cellular targets to cure these disorders.

Selected publications

Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice
Eléonore Bertin, Audrey Martinez, Anne Fayoux, Kevin Carvalho, Sara Carracedo, Pierre-Olivier Fernagut, Friedrich Koch-Nolte, David Blum, Sandrine S. Bertrand, Eric Boué-Grabot
Cell. Mol. Life Sci.. 2022-07-19
10.1007/s00018-022-04461-5

Pain hypersensitivity in a pharmacological mouse model of attention-deficit/hyperactivity disorder.
Otmane Bouchatta, Franck Aby, Wahiba Sifeddine, Rabia Bouali-Benazzouz, Louison Brochoire, Houria Manouze, Pascal Fossat, Saadia Ba M’Hamed, Mohamed Bennis, Marc Landry
Proc. Natl. Acad. Sci. U.S.A.. 2022-07-19
10.1073/pnas.2114094119

Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders
Alexia Duveau, Eléonore Bertin, Eric Boué-Grabot
Neurosci. Bull.. 2020-09-05
10.1007/s12264-020-00570-y

A secretagogin locus of the mammalian hypothalamus controls stress hormone release
Roman A Romanov, Alán Alpár, Ming‐Dong Zhang, Amit Zeisel, André Calas, Marc Landry, Matthew Fuszard, Sally L Shirran, Robert Schnell, Árpád Dobolyi, Márk Oláh, Lauren Spence, Jan Mulder, Henrik Martens, Miklós Palkovits, Mathias Uhlen, Harald H Sitte, Catherine H Botting, Ludwig Wagner, Sten Linnarsson, Tomas Hökfelt, Tibor Harkany
EMBO J. 2014-11-27
10.15252/embj.201488977

ATP P2X receptors downregulate AMPA receptor trafficking and postsynaptic efficacy in hippocampal neurons.
Johan-Till Pougnet, Estelle Toulme, Audrey Martinez, Daniel Choquet, Eric Hosy, Eric Boué-Grabot
Neuron. 2014-07-01
10.1016/j.neuron.2014.06.005