Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space
J. Estaun-Panzano, S. Nandi, Q. Gresil, E. Doudnikoff, C. Mazzocco, ML. Arotcarena, MH. Canron, B. Dehay, L. Cognet, E. Bezard
npj Parkinsons Dis.. 2024-12-30
10.1038/s41531-024-00850-8

Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates
Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay
npj Parkinsons Dis.. 2024-08-01
10.1038/s41531-024-00757-4

Modeling Parkinson's Disease in Primates
Erwan Bezard, Margaux Teil, Marie-Laure Arotcarena, Gregory Porras, Qin Li, Benjamin Dehay
Cold Spring Harb Perspect Med. 2024-06-10
10.1101/cshperspect.a041612

Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
Francesca De Giorgi, Ænora Letourneur, Marianna Kashyrina, Federica Zinghirino, Sandra Dovero, Nathalie Dutheil, Leslie-Ann Largitte, Marie-Laure Arotçarena, Erwan Bezard, Marie-Hélène Canron, Wassilios Meissner, Francesco De Nuccio, Dario Domenico Lofrumento, Florent Laferrière, François Ichas
Preprint - Research Square. 2024-02-07
10.21203/rs.3.rs-3921168/v1

Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A. Obeso, Erwan Bezard, Benjamin Dehay
npj Parkinsons Dis.. 2023-09-19
10.1038/s41531-023-00579-w

Monitoring α-synuclein aggregation.
Juan Estaun-Panzano, Marie-Laure Arotcarena, Erwan Bezard
Neurobiology of Disease. 2023-01-01
10.1016/j.nbd.2022.105966

Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Ines Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Michele Morari, Wassilios G Meissner, María Trinidad Herrero, Miquel Vila, Jose A Obeso, Erwan Bezard, Benjamin Dehay
Brain. 2022-03-14
10.1093/brain/awab374

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
Marie-Laure Arotcarena, Sandra Dovero, Nathalie Biendon, Nathalie Dutheil, Vincent Planche, Erwan Bezard, Benjamin Dehay
Front. Bioeng. Biotechnol.. 2021-11-15
10.3389/fbioe.2021.762209

Lack of limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment
Morgane Darricau, Marie-Hélène Canron, Marion Bosc, Marie-Laure Arotçarena, Mégane Le Quang, Benjamin Dehay, Erwan Bezard, Vincent Planche
Neurobiology of Aging. 2021-11-01
10.1016/j.neurobiolaging.2021.07.009

A New Rise of Non-Human Primate Models of Synucleinopathies
Margaux Teil, Marie-Laure Arotcarena, Benjamin Dehay
Biomedicines. 2021-03-09
10.3390/biomedicines9030272

Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
Federico N. Soria, Chiara Paviolo, Evelyne Doudnikoff, Marie-Laure Arotcarena, Antony Lee, Noémie Danné, Amit Kumar Mandal, Philippe Gosset, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezard
Nat Commun. 2020-07-10
10.1038/s41467-020-17328-9

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. T. Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard
Sci. Adv.. 2020-05-01
10.1126/sciadv.aaz9165

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
Marie-Laure Arotcarena, Sandra Dovero, Alice Prigent, Mathieu Bourdenx, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Maddalena Tasselli, Philippe Aubert, Niels Kruse, Brit Mollenhauer, Ines Trigo Damas, Cristina Estrada, Nuria Garcia-Carrillo, Nishant N Vaikath, Omar M A El-Agnaf, Maria Trinidad Herrero, Miquel Vila, Jose A Obeso, Pascal Derkinderen, Benjamin Dehay, Erwan Bezard
Brain. 2020-05-01
10.1093/brain/awaa096

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. Trinidad Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard
. 2019-10-31
10.1101/825216

Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard, Benjamin Dehay
JCI Insight. 2019-08-22
10.1172/jci.insight.129719

Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery
Marie-Laure Arotcarena, Margaux Teil, Benjamin Dehay
Cells. 2019-06-09
10.3390/cells8060565

Are synucleinopathies prion-like disorders?,Les synucléinopathies sont-elles des maladies à prions ?
M.-L. Arotçarena, B. Dehay
Pratique Neurologique - FMC. 2018-04-01
10.1016/j.praneu.2018.02.006