Biases in α-synuclein immuno-quantitation: a core problem for basic and ancillary studies of Parkinson’s disease and multiple system atrophy
Florent Laferrière, Ludivine Sabatier, Stéphane Claverol, Francesca De Giorgi, François Ichas
Transl Neurodegener. 2024-03-25
10.1186/s40035-024-00408-x

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
Marian Hruska-Plochan, Vera I. Wiersma, Katharina M. Betz, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D. Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann, Magdalini Polymenidou
Nature. 2024-02-14
10.1038/s41586-024-07042-7

Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
Francesca De Giorgi, Ænora Letourneur, Marianna Kashyrina, Federica Zinghirino, Sandra Dovero, Nathalie Dutheil, Leslie-Ann Largitte, Marie-Laure Arotçarena, Erwan Bezard, Marie-Hélène Canron, Wassilios Meissner, Francesco De Nuccio, Dario Domenico Lofrumento, Florent Laferrière, François Ichas
Preprint - Research Square. 2024-02-07
10.21203/rs.3.rs-3921168/v1

Oligodendrocytes Prune Axons Containing α-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?
Francesco De Nuccio, Marianna Kashyrina, Francesca Serinelli, Florent Laferrière, Dario Domenico Lofrumento, Francesca De Giorgi and François Ichas
biomolecules. 2023-02-01
10.3390/biom13020269

Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, François Ichas
Biomolecules. 2022-03-11
10.3390/biom12030436

Similar neuronal imprint and no cross-seeded fibrils in α-synuclein aggregates from MSA and Parkinson’s disease
Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas
npj Parkinsons Dis.. 2022-01-13
10.1038/s41531-021-00264-w

Similar neuronal imprint and absence of cross-seeded partner fibrils in α-synuclein aggregates from MSA and Parkinson’s disease brains
Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas
Preprint bioRxiv. 2021-06-22
10.1101/2021.06.22.449410

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy
Florent Laferrière, Xin He, Federica Zinghirino, Evelyne Doudnikoff, Emilie Faggiani, Wassilios G. Meissner, Erwan Bezard, Francesca De Giorgi, François Ichas
Cells. 2020-10-29
10.3390/cells9112371

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons
Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
Sci. Adv.. 2020-10-01
10.1126/sciadv.abc4364

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. T. Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard
Sci. Adv.. 2020-05-01
10.1126/sciadv.aaz9165

Crossing Species Barriers Relies on Structurally Distinct Prion Assemblies and Their Complementation
Angélique Igel-Egalon, Florent Laferrière, Philippe Tixador, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Juan Maria Torres, Hubert Laude, Human Rezaei, Vincent Béringue
Mol Neurobiol. 2020-04-01
10.1007/s12035-020-01897-3

Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts
Margaux Teil, Marie-Laure Arotcarena, Emilie Faggiani, Florent Laferriere, Erwan Bezard, Benjamin Dehay
Biomolecules. 2020-03-03
10.3390/biom10030391

Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons
Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
. 2020-02-12
10.1101/2020.02.11.943670

Complementation between pathological prion protein subassemblies to cross existing species barriers
Angélique Igel-Egalon, Florent Laferrière, Philippe Tixador, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Juan Maria Torres, Hubert Laude, Human Rezaei, Vincent Béringue
. 2019-12-03
10.1101/861278

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. Trinidad Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard
. 2019-10-31
10.1101/825216

Early stage prion assembly involves two subpopulations with different quaternary structures and a secondary templating pathway
Angélique Igel-Egalon, Florent Laferrière, Mohammed Moudjou, Jan Bohl, Mathieu Mezache, Tina Knäpple, Laetitia Herzog, Fabienne Reine, Christelle Jas-Duval, Marie Doumic, Human Rezaei, Vincent Béringue
Commun Biol. 2019-10-04
10.1038/s42003-019-0608-y

Quaternary structural convergence and structural diversification of prion assemblies at the early replication stage
Angélique Igel-Egalon, Florent Laferrière, Mohammed Moudjou, Mathieu Merzach, Tina Knäpple, Laetitia Herzog, Fabienne Reine, Marie Doumic, Human Rezaei, Vincent Béringue
. 2019-03-20
10.1101/583781

SarkoSpin: A Technique for Biochemical Isolation and Characterization of Pathological TDP-43 Aggregates
Pérez-Berlanga Manuela, Laferrière Florent, Polymenidou Magdalini
BIO-PROTOCOL. 2019-01-01
10.21769/bioprotoc.3424

TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Florent Laferrière, Zuzanna Maniecka, Manuela Pérez-Berlanga, Marian Hruska-Plochan, Larissa Gilhespy, Eva-Maria Hock, Ulrich Wagner, Tariq Afroz, Paul J. Boersema, Gery Barmettler, Sandrine C. Foti, Yasmine T. Asi, Adrian M. Isaacs, Ashraf Al-Amoudi, Amanda Lewis, Henning Stahlberg, John Ravits, Francesca De Giorgi, François Ichas, Erwan Bezard, Paola Picotti, Tammaryn Lashley, Magdalini Polymenidou
Nat Neurosci. 2018-12-17
10.1038/s41593-018-0294-y

Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis
Ali Jawaid, Bisrat T. Woldemichael, Eloïse A. Kremer, Florent Laferriere, Niharika Gaur, Tariq Afroz, Magdalini Polymenidou, Isabelle M. Mansuy
Mol Neurobiol. 2018-08-20
10.1007/s12035-018-1314-3

Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function
Eva-Maria Hock, Zuzanna Maniecka, Marian Hruska-Plochan, Stefan Reber, Florent Laferrière, Sonu Sahadevan M.K., Helena Ederle, Lauren Gittings, Lucas Pelkmans, Luc Dupuis, Tammaryn Lashley, Marc-David Ruepp, Dorothee Dormann, Magdalini Polymenidou
Cell Reports. 2018-07-01
10.1016/j.celrep.2018.06.094

Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution
T. Afroz, E.-M. Hock, P. Ernst, C. Foglieni, M. Jambeau, L. Gilhespy, F. Laferriere, Z. Maniecka, A. Plueckthun, P. Mittl, P. Paganetti, F.H.T. Allain, M. Polymenidou
. 2017-07-05
10.2210/pdb5mdi/pdb

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation
Tariq Afroz, Eva-Maria Hock, Patrick Ernst, Chiara Foglieni, Melanie Jambeau, Larissa A. B. Gilhespy, Florent Laferriere, Zuzanna Maniecka, Andreas Plückthun, Peer Mittl, Paolo Paganetti, Frédéric H. T. Allain, Magdalini Polymenidou
Nat Commun. 2017-06-29
10.1038/s41467-017-00062-0

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.
Henning Leske, Simone Hornemann, Uli Simon Herrmann, Caihong Zhu, Paolo Dametto, Bei Li, Florent Laferriere, Magdalini Polymenidou, Pawel Pelczar, Regina Rose Reimann, Petra Schwarz, Elisabeth Jane Rushing, Kurt Wüthrich, Adriano Aguzzi
PLoS ONE. 2017-02-16
10.1371/journal.pone.0170503

Advances and challenges in understanding the multifaceted pathogenesis of amyotrophic lateral sclerosis.
F Laferriere, M Polymenidou
Swiss Med Wkly. 2015-01-30
10.4414/smw.2015.14054

Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification.
M. Moudjou, P. Sibille, G. Fichet, F. Reine, J. Chapuis, L. Herzog, E. Jaumain, F. Laferriere, C.-A. Richard, H. Laude, O. Andreoletti, H. Rezaei, V. Beringue
mBio. 2013-12-31
10.1128/mbio.00829-13

Quaternary Structure of Pathological Prion Protein as a Determining Factor of Strain-Specific Prion Replication Dynamics
Florent Laferrière, Philippe Tixador, Mohammed Moudjou, Jérôme Chapuis, Pierre Sibille, Laetitia Herzog, Fabienne Reine, Emilie Jaumain, Hubert Laude, Human Rezaei, Vincent Béringue
PLoS Pathog. 2013-10-10
10.1371/journal.ppat.1003702