Isolation of Hypothalamic Microglia from Freshly Perfused Adult Mouse Brain by Magnetic-Activated Cell Sorting
Evangelia Kyriakidou, Giulia Cutugno, Camille Allard, Agnes Nadjar
JoVE. 2024-09-06
10.3791/66769

Rethinking the role of microglia in obesity
G. Cutugno, E. Kyriakidou, A. Nadjar
Neuropharmacology. 2024-04-01
10.1016/j.neuropharm.2024.109951

Discovery of a new type of neuroimmune interaction in the aged brain's response to energy surfeit
Agnes Nadjar
Brain, Behavior, and Immunity. 2023-03-01
10.1016/j.bbi.2023.03.010

Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice
Katherine Picard, Giorgio Corsi, Fanny Decoeur, Maria Amalia Di Castro, Maude Bordeleau, Marine Persillet, Sophie Layé, Cristina Limatola, Marie-Ève Tremblay, Agnès Nadjar
Brain, Behavior, and Immunity. 2023-01-01
10.1016/j.bbi.2022.09.016

Microglia states and nomenclature: A field at its crossroads
Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, (...) Agnes Nadjar, (...), Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray
Neuron. 2022-11-01
10.1016/j.neuron.2022.10.020

Nanoparticles: The new promise for region-specific targeting of microglia
Agnes Nadjar
Matter. 2022-08-01
10.1016/j.matt.2022.06.048

Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia
Noelia Rodríguez-Iglesias, Agnès Nadjar, Amanda Sierra, Jorge Valero
Int. J. Mol. Sci.. 2022-03-21
10.3390/ijms23063399

N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Layé, Marie-Eve Tremblay, Agnès Nadjar
Front. Cell. Neurosci.. 2022-02-10
10.3389/fncel.2022.802411

Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
Julia De Meij, Zain Alfanek, Lydie Morel, Fanny Decoeur, Quentin Leyrolle, Katherine Picard, Micael Carrier, Agnes Aubert, Alexandra Séré, Céline Lucas, Gerald Laforest, Jean-Christophe Helbling, Marie-Eve Tremblay, Daniela Cota, Marie-Pierre Moisan, Giovanni Marsicano, Sophie Layé, Agnès Nadjar
Cannabis and Cannabinoid Research. 2021-12-01
10.1089/can.2020.0170

Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis
Julien Bourel, Vincent Planche, Nadège Dubourdieu, Aymeric Oliveira, Alexandra Séré, Eva-Gunnel Ducourneau, Marion Tible, Marlène Maitre, Thierry Lesté-Lasserre, Agnes Nadjar, Aline Desmedt, Philippe Ciofi, Stéphane H. Oliet, Aude Panatier, Thomas Tourdias
Neurobiology of Disease. 2021-12-01
10.1016/j.nbd.2021.105533

N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Brière, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony‐Lee Sterley, Clémentine Bosch‐Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie‐Kim St‐Pierre, Maude Bordeleau, Véronique De Smedt‐Peyrusse, Alexandran Séré, Leslie Schwendimann, Stephane Grégoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie‐Eve Tremblay, Sophie Layé, Agnes Nadjar
Glia. 2021-09-14
10.1002/glia.24088

Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle
Giorgio Corsi, Katherine Picard, Maria Amalia Castro, Stefano Garofalo, Federico Tucci, Giuseppina Chece, Claudio Percio, Maria Teresa Golia, Marcello Raspa, Ferdinando Scavizzi, Fanny Decoeur, Clotilde Lauro, Mara Rigamonti, Fabio Iannello, Davide Antonio Ragozzino, Eleonora Russo, Giovanni Bernardini, Agnès Nadjar, Marie Eve Tremblay, Claudio Babiloni, Laura Maggi, Cristina Limatola
Glia. 2021-09-06
10.1002/glia.24090

Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?
Stéphane Léon, Agnès Nadjar, Carmelo Quarta
IJMS. 2021-05-15
10.3390/ijms22105243

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. D. Greenhalgh, J. C. Delpech, M. Martinat, C. Bosch-Bouju, J. Bourel, B. Rani, C. Lacabanne, A. Thomazeau, K. E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. Acar, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M. E. Tremblay, R. P. Bazinet, C. Joffre, A. Nadjar, S. Layé
Nat Commun. 2020-11-30
10.1038/s41467-020-19861-z

Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
Q. Leyrolle, F. Decoeur, G. Briere, C. Amadieu, A. R. A. A. Quadros, I. Voytyuk, C. Lacabanne, A. Benmamar-Badel, J. Bourel, A. Aubert, A. Sere, F. Chain, L. Schwendimann, B. Matrot, T. Bourgeois, S. Grégoire, J. G. Leblanc, A. De Moreno De Leblanc, P. Langella, G. R. Fernandes, L. Bretillon, C. Joffre, R. Uricaru, P. Thebault, P. Gressens, J. M. Chatel, S. Layé, A. Nadjar
Neuropsychopharmacol.. 2020-08-11
10.1038/s41386-020-00793-7

Role of Glia in the Regulation of Sleep in Health and Disease.
Stefano Garofalo, Katherine Picard, Cristina Limatola, Agnès Nadjar, Olivier Pascual, Marie‐Ève Tremblay
Comprehensive Physiology. 2020-03-12
10.1002/cphy.c190022

Direct and indirect effects of lipids on microglia function
Q. Leyrolle, S. Layé, A. Nadjar
Neuroscience Letters. 2019-08-01
10.1016/j.neulet.2019.134348

Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression
Richard P. Bazinet, Adam H. Metherel, Chuck T. Chen, Saame Raza Shaikh, Agnes Nadjar, Corinne Joffre, Sophie Layé
Brain, Behavior, and Immunity. 2019-07-01
10.1016/j.bbi.2019.07.001

Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice
F. Decoeur, A. Benmamar-Badel, Q. Leyrolle, M. Persillet, S. Layé, A. Nadjar
Brain, Behavior, and Immunity. 2019-05-01
10.1016/j.bbi.2019.05.016

Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
C. Rey, J.C. Delpech, C. Madore, A. Nadjar, A.D. Greenhalgh, C. Amadieu, A. Aubert, V. Pallet, C. Vaysse, S. Layé, C. Joffre
Brain, Behavior, and Immunity. 2019-02-01
10.1016/j.bbi.2018.07.025

Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation.
V.F. Labrousse, Q. Leyrolle, C. Amadieu, A. Aubert, A Sere, E. Coutureau, S. Grégoire, L. Bretillon, V. Pallet, P. Gressens, C. Joffre, A. Nadjar, S. Layé
Brain, Behavior, and Immunity. 2018-10-01
10.1016/j.bbi.2018.06.004

Role of metabolic programming in the modulation of microglia phagocytosis by lipids.
A. Nadjar
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-08-01

Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring
Charlotte Rey, Agnès Nadjar, Florent Joffre, Camille Amadieu, Agnès Aubert, Carole Vaysse, Véronique Pallet, Sophie Layé, Corinne Joffre
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-06-01
10.1016/j.plefa.2018.04.003

Antiinflammatory Properties of Dietary n-3 Polyunsaturated Fatty Acids Protect Against Cognitive Decline in Aging and Neurodegenerative Diseases
Agnes Nadjar, Quentin Leyrolle, Corinne Joffre, Sophie Layé
Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases. 2018-01-01

Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology
Sophie Layé, Agnès Nadjar, Corinne Joffre, Richard P. Bazinet
Pharmacol Rev. 2017-12-07
10.1124/pr.117.014092

Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology
A. Nadjar, Q. Leyrolle, C. Joffre, S. Laye
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01
10.1016/j.pnpbp.2016.07.004

Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
Agnes Nadjar, Henna-Kaisa M. Wigren, Marie-Eve Tremblay
Front. Cell. Neurosci.. 2017-08-30
10.3389/fncel.2017.00250

Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation.
Caroline André, Omar Guzman-Quevedo, Charlotte Rey, Julie Rémus-Borel, Samantha Clark, Ashley Castellanos-Jankiewicz, Elodie Ladeveze, Thierry Leste-Lasserre, Agnes Nadjar, Djoher Nora Abrous, Sophie Laye, Daniela Cota
Diabetes. 2016-11-30
10.2337/db16-0586

Modulation of brain PUFA content in different experimental models of mice
Corinne Joffre, Stéphane Grégoire, Véronique De Smedt, Niyazi Acar, Lionel Bretillon, Agnès Nadjar, Sophie Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-11-01
10.1016/j.plefa.2016.09.003

Enriched dairy fat matrix diet prevents early life lipopolysaccharide-induced spatial memory impairment at adulthood
A.L. Dinel, C. Rey, C. Baudry, C. Fressange-Mazda, P. Le Ruyet, A. Nadjar, P. Pallet, C. Joffre, S. Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-10-01
10.1016/j.plefa.2016.08.013

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra
PLoS Biol. 2016-09-20

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.

PLoS Biol. 2016-09-20
10.1371/journal.pbio.1002554

Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro
C. Rey, A. Nadjar, B. Buaud, C. Vaysse, A. Aubert, V. Pallet, S. Layé, C. Joffre
Brain, Behavior, and Immunity. 2016-07-01
10.1016/j.bbi.2015.12.013

N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer’s disease
Sophie Layé, Charlotte Madore, Isabelle St-Amour, Jean-Christophe Delpech, Corinne Joffre, Agnès Nadjar, Frédéric Calon
NUA. 2015-05-21

Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission
J.-C. Delpech, N. Saucisse, S. L. Parkes, C. Lacabanne, A. Aubert, F. Casenave, E. Coutureau, N. Sans, S. Laye, G. Ferreira, A. Nadjar
Journal of Neuroscience. 2015-02-18
10.1523/jneurosci.3028-14.2015

Neuroinflammation and aging: Influence of dietary n-3 polyunsaturated fatty acid
Sophie Layé, Jean-Christophe Delpech, Véronique De Smedt-Peyrusse, Corinne Joffre, Thomas Larrieu, Charlotte Madore, Agnès Nadjar and Lucile Capuron
OCL. 2011-11-15
10.1684/ocl.2011.0412

Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats
Karine Palin, Marie L. Moreau, Julie Sauvant, Hélène Orcel, Agnès Nadjar, Anne Duvoid-Guillou, Jennifer Dudit, Alain Rabié, Françoise Moos
American Journal of Physiology-Endocrinology and Metabolism. 2009-06-01

Shaping of motor responses by incentive values through the basal ganglia.
B. Pasquereau, A. Nadjar, D. Arkadir, E. Bezard, M. Goillandeau, B. Bioulac, C. E. Gross, T. Boraud
Journal of Neuroscience. 2007-01-31
10.1523/jneurosci.3745-06.2007

Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia.
Nadjar A, Brotchie JM, Guigoni C, Li Q, Zhou SB, Wang GJ, Ravenscroft P, Georges F, Crossman AR, Bezard E.
Journal of Neuroscience. 2006-08-23
10.1523/jneurosci.2582-06.2006

Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei
Agnès Nadjar, Rose-Marie Bluthé, Michael J May, Robert Dantzer, Patricia Parnet
Neuropsychopharmacol. 2005-05-18

NFκB Activates in vivo the Synthesis of Inducible Cox-2 in the Brain
Agnès Nadjar, Viviane Tridon, Michael J May, Sankar Ghosh, Robert Dantzer, Thierry Amédée, Patricia Parnet
J Cereb Blood Flow Metab. 2005-03-09

Signaling pathways of interleukin-1 actions in the brain: anatomical distribution of phospho-ERK1/2 in the brain of rat treated systemically with interleukin-1beta.
A. Nadjar, C. Combe, P. Busquet, R. Dantzer, P. Parnet
Neuroscience. 2005-01-01
1104537600

Book review: Interleukin protocols, methods in molecular medicine, vol. 70
Agnès Nadjar, Robert Dantzer
Psychoneuroendocrinology. 2003-04-01
10.1016/s0306-4530(02)00071-9