Alteration of IGF-1 bioavailability due to PAPPA2 deficiency leads to sex-specific metabolic disturbances
Antonio J. López-Gambero, Antonio Vargas, María del Mar Fernández-Arjona, Leticia Rubio, Marialuisa de Ceglia, Carlos Vera-Fernández, Ana Campillo-Calatayud, Patricia Rivera, Fernando Rodríguez de Fonseca, Vicente Barrios, Julie A. Chowen, Jesús Argente, Juan Suárez
Metabolism. 2025-10-01
10.1016/j.metabol.2025.156355

Early Oral Administration of D-Chiro-Inositol Reverses Hippocampal Insulin and Glutamate Signaling Deficits in the 3×Tg Humanized Mouse Model of Alzheimer’s Disease
Beatriz Pacheco-Sánchez, Julia Verheul-Campos, Antonio Vargas, Rubén Tovar, Miguel Rodríguez-Pozo, Juan A. Navarro, Antonio J. López-Gambero, Elena Baixeras, Pedro J. Serrano-Castro, Juan Suárez, Carlos Sanjuan, Patricia Rivera, Fernando Rodríguez de Fonseca
Nutrients. 2025-09-22
10.3390/nu17183024

Blood levels of cytokines highlight the role of inflammation in Alzheimer's disease.
Lorenzo Campanelli, Pablo Galeano, Federico A. Prestia, Carolina Cuesta, Maria C. Dalmasso, María Flores-López, Cristian Gona, Nicolás Irureta, Claudia Kairiyama, Julieta Lisso, Antonio Jesús López-Gambero, Ines Mintz, Nancy Medel, Karen S. Campuzano, Carolina Muchnik, Gisela V. Novack, Natividad Olivar, Ivana Quiroga, Nerea Requena-Ocaña, Jose Antonio Reyes-Bueno, Pedro Serrano-Castro, Zulma Sevillano, Patricia Solis, Juan Suárez, Ivana Villella, Nancy Wukitsevits, Eduardo M. Castaño, Fernando Taragano, Silvia Kochen, Daniel G. Politis, Luis I. Brusco, Fernando Rodríguez de Fonseca, Laura Morelli
Heliyon. 2025-01-01
10.1016/j.heliyon.2025.e41725

Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer’s Amyloidosis
Dina Medina-Vera, Antonio J. López-Gambero, Julia Verheul, Juan A. Navarro, Laura Morelli, Pablo Galeano, Juan Suárez, Carlos Sanjuan, Beatriz Pacheco-Sánchez, Patricia Rivera, Francisco J. Pavon-Morón, Cristina Rosell-Valle, Fernando Rodríguez de Fonseca
Nutrients. 2024-12-04
10.3390/nu16234186

Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments.
María del Mar Fernández-Arjona, Juan Antonio Navarro, Antonio Jesús López-Gambero, Marialuisa de Ceglia, Miguel Rodríguez, Leticia Rubio, Fernando Rodríguez de Fonseca, Vicente Barrios, Julie A. Chowen, Jesús Argente, Patricia Rivera, Juan Suárez
Biol Sex Differ. 2024-04-08
10.1186/s13293-024-00603-5

A sympathetic brake on gut GLP-1 release
Antonio J. López-Gambero, Victor Jouque, Daniela Cota
Neuron. 2024-03-01
10.1016/j.neuron.2024.02.015

mTORC1 in energy expenditure: consequences for obesity
Camille Allard, Cristina Miralpeix, Antonio J. López-Gambero, Daniela Cota
Nat Rev Endocrinol. 2024-01-15
10.1038/s41574-023-00934-0

Novel insights into D-Pinitol based therapies: a link between tau hyperphosphorylation and insulin resistance.
Dina Medina-Vera, Antonio Jesús López-Gambero, Juan Antonio Navarro, Carlos Sanjuan, Elena Baixeras, Juan Decara, Fernando Rodríguez de Fonseca
Neural Regeneration Research. 2023-07-07
10.4103/1673-5374.379015

Pharmacokinetics and Endocrine Effects of an Oral Dose of D-Pinitol in Human Fasting Healthy Volunteers
Juan A. Navarro, Caridad Díaz, Juan Decara, Dina Medina-Vera, Antonio J. Lopez-Gambero, Juan Suarez, Francisco Javier Pavón, Antonia Serrano, Antonio Vargas, Ana Luisa Gavito, Oscar Porras-Perales, Jesús Aranda, Francisca Vicente, Carlos Sanjuan, Elena Baixeras, Fernando Rodríguez de Fonseca
Nutrients. 2022-10-01
10.3390/nu14194094

Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes
Juan A. Navarro, Juan Decara, Dina Medina-Vera, Ruben Tovar, Antonio J. Lopez-Gambero, Juan Suarez, Francisco Javier Pavón, Antonia Serrano, Marialuisa de Ceglia, Carlos Sanjuan, Yolanda Alfonso Baltasar, Elena Baixeras, Fernando Rodríguez de Fonseca
Pharmaceutics. 2022-07-30
10.3390/pharmaceutics14081594

d ‐Pinitol promotes tau dephosphorylation through a cyclin‐dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?
Dina Medina‐Vera, Juan Antonio Navarro, Patricia Rivera, Cristina Rosell‐Valle, Alfonso Gutiérrez‐Adán, Carlos Sanjuan, Antonio Jesús López‐Gambero, Rubén Tovar, Juan Suárez, Francisco Javier Pavón, Elena Baixeras, Juan Decara, Fernando Rodríguez de Fonseca
British J Pharmacology. 2022-07-18
10.1111/bph.15907

A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer’s Disease, the 5XFAD Mouse
Antonio J. López-Gambero, Cristina Rosell-Valle, Dina Medina-Vera, Juan Antonio Navarro, Antonio Vargas, Patricia Rivera, Carlos Sanjuan, Fernando Rodríguez de Fonseca, Juan Suárez
IJMS. 2021-05-20
10.3390/ijms22105365

Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with Pappa2 Deficiency
Leticia Rubio, Antonio Vargas, Patricia Rivera, Antonio J. López-Gambero, Rubén Tovar, Julian K. Christians, Stella Martín-de-las-Heras, Fernando Rodríguez de Fonseca, Julie A. Chowen, Jesús Argente, Juan Suárez
IJMS. 2021-04-14
10.3390/ijms22084048

Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer’s Disease in a Preclinical Model: A Therapeutic Opportunity
Dina Medina-Vera, Cristina Rosell-Valle, Antonio J. López-Gambero, Juan A. Navarro, Emma N. Zambrana-Infantes, Patricia Rivera, Luis J. Santín, Juan Suarez, Fernando Rodríguez de Fonseca
Biology. 2020-11-05
10.3390/biology9110377

The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases
Antonio J. López-Gambero, Carlos Sanjuan, Pedro Jesús Serrano-Castro, Juan Suárez, Fernando Rodríguez de Fonseca
Biomedicines. 2020-08-20
10.3390/biomedicines8090295

Energy sensors in drug addiction: A potential therapeutic target
Antonio Jesús López‐Gambero, Fernando Rodríguez de Fonseca, Juan Suárez
Addiction Biology. 2020-07-07
10.1111/adb.12936

Peroxisome Proliferator-Activated Receptors: Experimental Targeting for the Treatment of Inflammatory Bowel Diseases
Juan Decara, Patricia Rivera, Antonio Jesús López-Gambero, Antonia Serrano, Francisco Javier Pavón, Elena Baixeras, Fernando Rodríguez de Fonseca, Juan Suárez
Front. Pharmacol.. 2020-05-27
10.3389/fphar.2020.00730

Differential hepatoprotective role of the cannabinoid CB1 and CB2 receptors in acetaminophen‐induced liver injury
Patricia Rivera, Antonio Vargas, Antoni Pastor, Anna Boronat, Antonio Jesús López‐Gambero, Laura Sánchez‐Marín, Dina Medina‐Vera, Antonia Serrano, Francisco Javier Pavón, Rafael Torre, Ekaitz Agirregoitia, María Isabel Lucena, Fernando Rodríguez de Fonseca, Juan Decara, Juan Suárez
Br J Pharmacol. 2020-04-15
10.1111/bph.15051

Epicardial cell lineages and the origin of the coronary endothelium
Rita Carmona, Silvia Barrena, Antonio Jesús López Gambero, Anabel Rojas, Ramón Muñoz‐Chápuli
The FASEB Journal. 2020-02-18
10.1096/fj.201902249RR

The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats
Juan Decara, Antonia Serrano, Francisco Javier Pavón, Patricia Rivera, Rocio Arco, Ana Gavito, Antonio Vargas, Juan A. Navarro, Ruben Tovar, Antonio J. Lopez-Gambero, Ana Martínez, Juan Suárez, Fernando Rodríguez de Fonseca, Elena Baixeras
Sci Rep. 2018-06-29
10.1038/s41598-018-27871-7

Brain Glucose-Sensing Mechanism and Energy Homeostasis
A. J. López-Gambero, F. Martínez, K. Salazar, M. Cifuentes, F. Nualart
Mol Neurobiol. 2018-05-24
10.1007/s12035-018-1099-4

SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies
Katterine Salazar, Fernando Martínez, Margarita Pérez-Martín, Manuel Cifuentes, Laura Trigueros, Luciano Ferrada, Francisca Espinoza, Natalia Saldivia, Romina Bertinat, Katherine Forman, María José Oviedo, Antonio J. López-Gambero, Christian Bonansco, Ernesto R. Bongarzone, Francisco Nualart
Mol Neurobiol. 2017-09-23
10.1007/s12035-017-0762-5