Biases in α-synuclein immuno-quantitation: a core problem for basic and ancillary studies of Parkinson’s disease and multiple system atrophy
Florent Laferrière, Ludivine Sabatier, Stéphane Claverol, Francesca De Giorgi, François Ichas
Transl Neurodegener. 2024-03-25
10.1186/s40035-024-00408-x

Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
Francesca De Giorgi, Ænora Letourneur, Marianna Kashyrina, Federica Zinghirino, Sandra Dovero, Nathalie Dutheil, Leslie-Ann Largitte, Marie-Laure Arotçarena, Erwan Bezard, Marie-Hélène Canron, Wassilios Meissner, Francesco De Nuccio, Dario Domenico Lofrumento, Florent Laferrière, François Ichas
Preprint - Research Square. 2024-02-07
10.21203/rs.3.rs-3921168/v1

Oligodendrocytes Prune Axons Containing α-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?
Francesco De Nuccio, Marianna Kashyrina, Francesca Serinelli, Florent Laferrière, Dario Domenico Lofrumento, Francesca De Giorgi and François Ichas
biomolecules. 2023-02-01
10.3390/biom13020269

A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine Induces Potent Immune Responses and Therapeutic Efficacy in Mice
Sabine Schmidhuber, Sandra Scheiblhofer, Richard Weiss, Mihály Cserepes, József Tóvári, Gabriele Gadermaier, Erwan Bezard, Francesca De Giorgi, Francois Ichas, Dirk Strunk, Markus Mandler
Vaccines. 2022-08-30
10.3390/vaccines10091432

α-Synuclein Fibrils as Penrose Machines: A Chameleon in the Gear
Francesca De Giorgi, Vladimir N. Uversky, François Ichas
Biomolecules. 2022-03-24
10.3390/biom12040494

Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, François Ichas
Biomolecules. 2022-03-11
10.3390/biom12030436

Similar neuronal imprint and no cross-seeded fibrils in α-synuclein aggregates from MSA and Parkinson’s disease
Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas
npj Parkinsons Dis.. 2022-01-13
10.1038/s41531-021-00264-w

Similar neuronal imprint and absence of cross-seeded partner fibrils in α-synuclein aggregates from MSA and Parkinson’s disease brains
Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas
Preprint bioRxiv. 2021-06-22
10.1101/2021.06.22.449410

NRF-1 and HIF-1α contribute to modulation of human VDAC1 gene promoter during starvation and hypoxia in HeLa cells
Francesca Guarino, Federica Zinghirino, Lia Mela, Xena Giada Pappalardo, François Ichas, Vito De Pinto, Angela Messina
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2020-12-01
10.1016/j.bbabio.2020.148289

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy
Florent Laferrière, Xin He, Federica Zinghirino, Evelyne Doudnikoff, Emilie Faggiani, Wassilios G. Meissner, Erwan Bezard, Francesca De Giorgi, François Ichas
Cells. 2020-10-29
10.3390/cells9112371

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons
Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
Sci. Adv.. 2020-10-01
10.1126/sciadv.abc4364

Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction
Zhenwei Yu, Min Shi, Tessandra Stewart, Pierre-Olivier Fernagut, Yang Huang, Chen Tian, Benjamin Dehay, Anzari Atik, Dishun Yang, Francesca De Giorgi, François Ichas, Marie-Hélène Canron, Roberto Ceravolo, Daniela Frosini, Han-Joon Kim, Tao Feng, Wassilios G Meissner, Jing Zhang
Brain. 2020-05-18
10.1093/brain/awaa110

TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Florent Laferrière, Zuzanna Maniecka, Manuela Pérez-Berlanga, Marian Hruska-Plochan, Larissa Gilhespy, Eva-Maria Hock, Ulrich Wagner, Tariq Afroz, Paul J. Boersema, Gery Barmettler, Sandrine C. Foti, Yasmine T. Asi, Adrian M. Isaacs, Ashraf Al-Amoudi, Amanda Lewis, Henning Stahlberg, John Ravits, Francesca De Giorgi, François Ichas, Erwan Bezard, Paola Picotti, Tammaryn Lashley, Magdalini Polymenidou
Nat Neurosci. 2018-12-17
10.1038/s41593-018-0294-y

In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains.
Fabio Cavaliere, Loic Cerf, Benjamin Dehay, Paula Ramos-Gonzalez, Francesca De Giorgi, Mathieu Bourdenx, Alban Bessede, Jose A. Obeso, Carlos Matute, François Ichas, Erwan Bezard
Neurobiology of Disease. 2017-07-01
10.1016/j.nbd.2017.04.011

The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer
C Rey, B Faustin, I Mahouche, R Ruggieri, C Brulard, F Ichas, I Soubeyran, L Lartigue & F De Giorgi
Oncogene. 2015-05
10.1038/onc.2015.379

A phase II trial evaluating the efficacy and safety of efavirenz in metastatic castration-resistant prostate cancer
Nadine Houédé, Marina Pulido, Loic Mourey, Florence Joly, Jean‐Marc Ferrero, Carine Bellera, Frank Priou, Caroline Lalet, Audrey Laroche‐Clary, Mireille Canal Raffin, François Ichas, Alain Puech, Pierre Vincenzo Piazza
The Oncologist. 2014-10-29
10.1634/theoncologist.2014-0345

HIPK1 drives p53 activation to limit colorectal cancer cell growth
Christophe Rey, Isabelle Soubeyran, Isabelle Mahouche, Stephane Pedeboscq, Alban Bessede, François Ichas, Francesca De Giorgi, Lydia Lartigue
Cell Cycle. 2013-06-15
10.4161/cc.24927

High-Throughput Flow Cytometry Analysis of Apoptosis
Francesca de Giorgi, François Ichas
High-Throughput Screening Methods in Toxicity Testing. 2013-03-04
10.1002/9781118538203.ch6

Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines
Stéphane Pédeboscq, Denis Gravier, Françoise Casadebaig, Geneviève Hou, Arnaud Gissot, Christophe Rey, François Ichas, Francesca De Giorgi, Lydia Lartigue, Jean-Paul Pometan
Bioorganic & Medicinal Chemistry. 2012-11-01
10.1016/j.bmc.2012.09.034

High-Throughput Flow Cytometry for Predicting Drug-Induced Hepatotoxicity
Marion Zanese, Laura Suter, Adrian Roth, Francesca De Giorgi, Francois Ichas
Clinical Flow Cytometry - Emerging Applications. 2012-05-16
10.5772/38270

Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein Kinase inhibitors in vitro
Stéphane Pédeboscq, Christophe Rey, Muriel Petit, Catherine Harpey, Francesca De Giorgi, François Ichas, Lydia Lartigue
PLoS ONE. 2012-05-08
10.1371/journal.pone.0036811

The polyphenolic ellagitannin vescalagin acts as a preferential catalytic inhibitor of the α isoform of human DNA topoisomerase II
Céline Auzanneau, Danièle Montaudon, Rémi Jacquet, Stéphane Puyo, Laurent Pouységu, Denis Deffieux, Assia Elkaoukabi-Chaibi, Francesca De Giorgi, François Ichas, Stéphane Quideau, Philippe Pourquier
Mol Pharmacol. 2012-04-23
10.1124/mol.111.077537

Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function
Isabelle Soubeyran, Isabelle Mahouche, Aude Grigoletto, Thierry Leste-Lasserre, Guillaume Drutel, Christophe Rey, Stephane Pedeboscq, France Blanchard, Veronique Brouste, Jean-Christophe Sabourin, Yves Bécouarn, Josy Reiffers, François Ichas, Francesca De Giorgi
The American Journal of Pathology. 2011-05-01
10.1016/j.ajpath.2011.01.021

Synthesis and study of antiproliferative activity of novel thienopyrimidines on glioblastoma cells
Stéphane Pédeboscq, Denis Gravier, Françoise Casadebaig, Geneviève Hou, Arnaud Gissot, Francesca De Giorgi, François Ichas, Jean Cambar, Jean-Paul Pometan
European Journal of Medicinal Chemistry. 2010-06-01
10.1016/j.ejmech.2010.02.032

Recombinant differential anchorage probes that tower over the spatial dimension of intracellular signals for high content screening and analysis
Laura Schembri, Marion Zanese, Gaelle Depierre-Plinet, Muriel Petit, Assia Elkaoukabi-Chaibi, Loic Tauzin, Cristina Florean, Lydia Lartigue, Chantal Medina, Christophe Rey, Francis Belloc, Josy Reiffers, François Ichas, Francesca De Giorgi
Anal. Chem.. 2009-12-01
10.1021/ac9015227

Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis
Flora Tomasello, Angela Messina, Lydia Lartigue, Laura Schembri, Chantal Medina, Simona Reina, Didier Thoraval, Marc Crouzet, François Ichas, Vito De Pinto, Francesca De Giorgi
Cell Res. 2009-08-11
10.1038/cr.2009.98

An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis
L. Lartigue, C. Medina, L. Schembri, P. Chabert, M. Zanese, F. Tomasello, R. Dalibart, D. Thoraval, M. Crouzet, F. Ichas, F. De Giorgi
Journal of Cell Science. 2008-10-07
10.1242/jcs.029587

High content analysis of γ-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer's disease
Cristina Florean, Enrico Zampese, Marion Zanese, Lucia Brunello, François Ichas, Francesca De Giorgi, Paola Pizzo
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2008-08-01
10.1016/j.bbamcr.2008.03.012

Protein arginine (N)-methyl transferase 7 (PRMT7) as a potential target for the sensitization of tumor cells to camptothecins
Vincent Verbiest, Danièle Montaudon, Michel T. Tautu, Joyce Moukarzel, Jean-Pierre Portail, Judith Markovits, Jacques Robert, François Ichas, Philippe Pourquier
FEBS Letters. 2008-03-31
10.1016/j.febslet.2008.03.031

Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway
M. Beneteau, M. Pizon, B. Chaigne-Delalande, S. Daburon, P. Moreau, F. De Giorgi, F. Ichas, A. Rebillard, M.-T. Dimanche-Boitrel, J.-L. Taupin, J.-F. Moreau, P. Legembre
Molecular Cancer Research. 2008-03-14
10.1158/1541-7786.mcr-07-0331

Tyrosine hydroxylase and dopamine transporter expression in lactotrophs from postlactating rats: Involvement in dopamine-induced apoptosis
Arnaud Jaubert, Guillaume Drutel, Thierry Leste-Lasserre, François Ichas, Laurence Bresson-Bepoldin
Endocrinology. 2007-06-01
10.1210/en.2006-1293

The HA tag is cleaved and loses immunoreactivity during apoptosis
Laura Schembri, Renee Dalibart, Flora Tomasello, Patrick Legembre, François Ichas, Francesca De Giorgi
Nat Methods. 2007-02-01
10.1038/nmeth0207-107

Label-free optical imaging of mitochondria in live cells
David Lasne, Gerhard A. Blab, Francesca De Giorgi, François Ichas, Brahim Lounis, Laurent Cognet
Opt. Express. 2007-01-01
10.1364/OE.15.014184

Signaling pathway involved in the pro-apoptotic effect of dopamine in the GH3 pituitary cell line
Arnaud Jaubert, François Ichas, Laurence Bresson-Bepoldin
Neuroendocrinology. 2006-01-01
10.1159/000094044

Amplification of Fas-Mediated Apoptosis in Type II Cells via Microdomain Recruitment
Patrick Legembre, Sophie Daburon, Patrick Moreau, François Ichas, Francesca de Giorgi, Jean-François Moreau, Jean-Luc Taupin
MCB. 2005-08-01
10.1128/mcb.25.15.6811-6820.2005

Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion
Naoual L Benali-Furet, Mounia Chami, Ludivine Houel, Francesca De Giorgi, Fabienne Vernejoul, David Lagorce, Louis Buscail, Ralf Bartenschlager, François Ichas, Rosario Rizzuto, Patrizia Paterlini-Bréchot
Oncogene. 2005-05-09
10.1038/sj.onc.1208673

Oligomeric Bax Is a Component of the Putative CytochromecRelease Channel MAC, Mitochondrial Apoptosis-induced Channel
Laurent M. Dejean, Sonia Martinez-Caballero, Liang Guo, Cynthia Hughes, Oscar Teijido, Thomas Ducret, François Ichas, Stanley J. Korsmeyer, Bruno Antonsson, Elizabeth A. Jonas, Kathleen W. Kinnally
MBoC. 2005-05-01
10.1091/mbc.e04-12-1111

Correlative Electron Tomography and Elemental Microanalysis in Biology
M. Marko, T.W. Wagenknecht, F. Ichas, P. Bernardi, C.A. Mannella
Microsc Microanal. 2003-07-24
10.1017/s143192760344590x

RGD-functionalized spherulites™ as targeted vectors captured by adherent cultured cells
P Chenevier, B Delord, J Amédée, R Bareille, F Ichas, D Roux
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2002-12-01
10.1016/S0167-4889(02)00313-0

Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases?
Jean Dessolin, Marie Schuler, Alice Quinart, Francesca De Giorgi, Leon Ghosez, François Ichas
European Journal of Pharmacology. 2002-07-01
10.1016/s0014-2999(02)01839-3

The permeability transition pore signals apoptosis by directing Bax translocation and multimerization.
Francesca De Giorgi, Lydia Lartigue, Manuel K. A. Bauer, Alexis Schubert, Stefan Grimm, George T. Hanson, S. James Remington, Richard J. Youle, François Ichas
FASEB j.. 2002-02-25
10.1096/fj.01-0269fje

Electrical coupling and plasticity of the mitochondrial network
F. De Giorgi, L. Lartigue, F. Ichas
Cell Calcium. 2000-11-01
10.1054/ceca.2000.0177

Time-resolved storage and retrieval of Ca2+ signals by mitochondria depends on matrix Ca2+ hotspots
François Ichas, Francesca Giorgi, Michel Duvert, Carmen A. Mannella, Michael Marko, Raffaele Colonna, Paolo Bernardi
Biology of the Cell. 1999-06-01
10.1016/s0248-4900(99)80046-x

A ubiquinone-binding site regulates the mitochondrial permeability transition pore
Eric Fontaine, François Ichas, Paolo Bernardi
J. Biol. Chem.. 1998-10-02
10.1074/jbc.273.40.25734

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state
François Ichas, Jean-Pierre Mazat
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1998-08-01
10.1016/s0005-2728(98)00119-4

Perspectives on the mitochondrial permeability transition
Paolo Bernardi, Emy Basso, Raffaele Colonna, Paola Costantini, Fabio Di Lisa, Ove Eriksson, Eric Fontaine, Michael Forte, François Ichas, Stefano Massari, Annamaria Nicolli, Valeria Petronilli, Luca Scorrano
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1998-06-01
10.1016/s0005-2728(98)00069-3

Regulation of the permeability transition pore in skeletal muscle mitochondria modulation by electron flow through the respiratory chain complex I
Eric Fontaine, Ove Eriksson, François Ichas, Paolo Bernardi
J. Biol. Chem.. 1998-05-15
10.1074/jbc.273.20.12662

A model of mitochondrial Ca2+-induced Ca2+ release simulating the Ca2+ oscillations and spikes generated by mitochondria
Vitalii A. Selivanov, François Ichas, Ekhson L. Holmuhamedov, Laurence S. Jouaville, Yuri V. Evtodienko, Jean-Pierre Mazat
Biophysical Chemistry. 1998-05-01
10.1016/s0301-4622(98)00127-6

A model of mitochondrial Ca2+-induced Ca2+ release simulating the Ca2+ oscillations and spikes generated by mitochondria
Vitalii A. Selivanov, François Ichas, Ekhson L. Holmuhamedov, Laurence S. Jouaville, Yuri V. Evtodienko, Jean-Pierre Mazat
Biophysical Chemistry. 1998-05-01
10.1016/S0301-4622(98)00127-6

Modulation of cell calcium signals by mitochondria
Laurence S. Jouaville, François Ichas, Jean-Pierre Mazat
Bioenergetics of the Cell: Quantitative Aspects. 1998-01-01
10.1007/978-1-4615-5653-4_24

The mitochondrial permeability transition
Paolo Bernardi, Raffaele Colonna, Paola Costantini, Ove Eriksson, Eric Fontaine, François Ichas, Stefano Massari, Annamaria Nicolli, Valeria Petronilli, Luca Scorrano
BioFactors. 1998-01-01
10.1002/biof.5520080315

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals
François Ichas, Laurence S Jouaville, Jean-Pierre Mazat
Cell. 1997-06-01
10.1016/s0092-8674(00)80301-3

Microtubule-active drugs suppress the closure of the permeability transition pore in tumour mitochondria
Yuri V. Evtodienko, Vera V. Teplova, Serguei S. Sidash, François Ichas, Jean-Pierre Mazat
FEBS Letters. 1996-09-09
10.1016/0014-5793(96)00875-7

Propofol and cellular calcium homeostasis [16]
Francois Sztark, Francois Ichas, Jean-Pierre Mazat, Philippe Dabadie
Anesthesiology. 1995-12-01
10.1097/00000542-199512000-00051

Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes
Laurence S. Jouaville, François Ichas, Ekhson L. Holmuhamedov, Patricia Camacho, James D. Lechleiter
Nature. 1995-10-01
10.1038/377438a0

Differential effects of verapamil and quinine on the reversal of doxorubicin resistance in a human leukemia cell line
Sanae Bennis, François Ichas, Jacques Robert
Int. J. Cancer. 1995-07-28
10.1002/ijc.2910620309

Effects of the anaesthetic propofol on the calcium-induced permeability transition of rat heart mitochondria: direct pore inhibition and shift of the gating potential
François Sztark, François Ichas, Rachid Ouhabi, Philippe Dabadie, Jean-Pierre Mazat
FEBS Letters. 1995-07-10
10.1016/0014-5793(95)00610-l

Action of testosterone on the estradiol-induced feminization of the male chick embryo
N. Faucounau, F. Ichas, R. Stoll, R. Maraud
Anat Embryol. 1995-04-01
10.1007/bf00534691

Action of testosterone on the anti-Müllerian activity of the chick embryonic testis assayed in vivo by organotypic grafting
F. Ichas, N. Faucounau, R. Stoll, R. Maraud
Anat Embryol. 1994-09-01
10.1007/bf00234307

EFFECTS OF PROPOFOL ON THE CALCIUM-INDUCED PERMEABILITY TRANSITION OF RAT HEART MITOCHONDRIA
F. Sztark, F. Ichas, R. Ouhabi, J. P. Mazat, P. Dabadie
Anesthesiology. 1994-09-01
10.1097/00000542-199409001-00733

Mitochondrial calcium spiking: A transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling
François Ichas, Laurence S. Jouaville, Sergueï S. Sidash, Jean-Pierre Mazat, Ekhson L. Holmuhamedov
FEBS Letters. 1994-07-11
10.1016/0014-5793(94)00615-6

Action of estradiol and tamoxifen on the testis-inducing activity of the chick embryonic testis grafted to the female embryo
R. Stoll, F. Ichas, N. Faucounau, R. Maraud
Anat Embryol. 1993-12-01
10.1007/BF00187014

Action of estradiol and tamoxifen on the Müllero-regressive activity of the chick embryonic testis assayed in vivo by organotypic grafting
R. Stoll, F. Ichas, N. Faucounau, R. Maraud
Anat Embryol. 1993-04-01
10.1007/bf00185896

Control of ATP Flux in Rat Muscle Mitochondria
Laurence Jouaville, François Ichas, Thierry Letellier, Monique Malgat, Jean-Pierre Mazat
Modern Trends in Biothermokinetics. 1993-01-01
10.1007/978-1-4615-2962-0_49